Q6CJ61

PR
Gene name
RIB7 (KLLA0F21120g)
Protein name
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
Names
DAROPP reductase, DARP reductase, 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase, DARIPP synthase
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F21120g
EC number
1.1.1.302: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CJ61

Entry ID Method Resolution Chain Position Source
AF-Q6CJ61-F1 Predicted AlphaFoldDB

No variants for Q6CJ61

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CJ61

No associated diseases with Q6CJ61

2 regional properties for Q6CJ61

Type Name Position InterPro Accession
domain Bacterial bifunctional deaminase-reductase, C-terminal 31 - 242 IPR002734
domain Riboflavin-specific deaminase, C-terminal 30 - 247 IPR011549

Functions

Description
EC Number 1.1.1.302 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-amino-6-(5-phosphoribosylamino)uracil reductase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

1 GO annotations of biological process

Name Definition
riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPIQPLKKEL VSFLEPYMPE NAGVLGEQEK PYVILTYAQS LDARIAKIKG TRTIISHQET
70 80 90 100 110 120
NTMTHYLRYK FDGIMLGCGT VLVDDPGLNC KWWPDDEPKP EHFAEHSPRP IILDPNGKWK
130 140 150 160 170 180
FEGSKMKTLF DSGDGKAPIV VVKKLPEVVE ENVDYLVMQT NFTGKVDWHD LFIQLKSQFG
190 200 210 220 230 240
LKSIMVEGGG IVINDLLQRP HLIDALVITV GATFLGSEGV EVSPLIEINL KDISWWKGTR
250
DSVLCSRLVS HS