Q6CII8

PR
Gene name
RNA14 (KLLA0F26290g)
Protein name
mRNA 3'-end-processing protein RNA14
Names
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_F26290g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q6CII8

Entry ID Method Resolution Chain Position Source
4E6H X-ray 230 A A 18-661 PDB
4E85 X-ray 300 A A/B 18-661 PDB
4EBA X-ray 330 A A/B/C/D/E/F 18-661 PDB
AF-Q6CII8-F1 Predicted AlphaFoldDB

No variants for Q6CII8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CII8

No associated diseases with Q6CII8

8 regional properties for Q6CII8

Type Name Position InterPro Accession
repeat HAT (Half-A-TPR) repeat 62 - 94 IPR003107-1
repeat HAT (Half-A-TPR) repeat 99 - 133 IPR003107-2
repeat HAT (Half-A-TPR) repeat 147 - 179 IPR003107-3
repeat HAT (Half-A-TPR) repeat 190 - 223 IPR003107-4
repeat HAT (Half-A-TPR) repeat 256 - 296 IPR003107-5
repeat HAT (Half-A-TPR) repeat 466 - 498 IPR003107-6
repeat HAT (Half-A-TPR) repeat 500 - 535 IPR003107-7
domain Suppressor of forked 416 - 591 IPR008847

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleus and/or cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
mRNA cleavage factor complex Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
pre-mRNA cleavage required for polyadenylation The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.
response to DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDGTATPDP LPSSSNTSTS LRPTSRVRDE SDVIGKLNDM IEEQPTDIFL YVKLLKHHVS
70 80 90 100 110 120
LKQWKQVYET FDKLHDRFPL MANIWCMRLS LEFDKMEELD AAVIEPVLAR CLSKELGNND
130 140 150 160 170 180
LSLWLSYITY VRKKNDIITG GEEARNIVIQ AFQVVVDKCA IFEPKSIQFW NEYLHFLEHW
190 200 210 220 230 240
KPVNKFEEQQ RVQYIRKLYK TLLCQPMDCL ESMWQRYTQW EQDVNQLTAR RHIGELSAQY
250 260 270 280 290 300
MNARSLYQDW LNITKGLKRN LPITLNQATE SNLPKPNEYD VQQLLIWLEW IRWESDNKLE
310 320 330 340 350 360
LSDDLHKARM TYVYMQAAQH VCFAPEIWFN MANYQGEKNT DSTVITKYLK LGQQCIPNSA
370 380 390 400 410 420
VLAFSLSEQY ELNTKIPEIE TTILSCIDRI HLDLAALMED DPTNESAINQ LKSKLTYVYC
430 440 450 460 470 480
VYMNTMKRIQ GLAASRKIFG KCRRLKKLVT PDIYLENAYI EYHISKDTKT ACKVLELGLK
490 500 510 520 530 540
YFATDGEYIN KYLDFLIYVN EESQVKSLFE SSIDKISDSH LLKMIFQKVI FFESKVGSLN
550 560 570 580 590 600
SVRTLEKRFF EKFPEVNKLE EFTNKYKVLD VNYLQRLELD YMVRDVMPEA IALDRGSNNL
610 620 630 640 650 660
KRTMREEEDG QAFKKFKANE DPIPPEIVEL LKVLPKRQYF KVTIFEAHAF SEFLSDKVTI
Q