Q6CIF0
Gene name |
CHL1 (KLLA0F27181g) |
Protein name |
ATP-dependent DNA helicase CHL1 |
Names |
Chromosome loss protein 1 |
Species |
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
KEGG Pathway |
kla:KLLA0_F27181g |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CIF0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CIF0-F1 | Predicted | AlphaFoldDB |
No variants for Q6CIF0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CIF0 | |||||
No associated diseases with Q6CIF0
5 regional properties for Q6CIF0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | 352 - 361 | IPR002464 |
| domain | Helicase-like, DEXD box c2 type | 3 - 402 | IPR006554 |
| domain | ATP-dependent helicase, C-terminal | 603 - 784 | IPR006555 |
| domain | RAD3-like helicase, DEAD | 205 - 378 | IPR010614 |
| domain | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | 1 - 415 | IPR014013 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| establishment of sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase. |
| interstrand cross-link repair | Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKNFHHPYQ | PYDIQTQLME | HIYELLNSGK | KVGIFESPTG | TGKTLSLICS | TVTWLREHKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKLNSKVDND | NLSDSTFSSS | DDEPEWVNQF | YNDKIMKEKS | KSLQEYENYL | EGLSMSNIKP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLRQLDIGDR | KRKKTVPRHI | EIEIEDDETN | FLPEPYEQDS | VSNQNDYEKG | QINDEIQKLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKIDKGYDVK | TENNMELKSP | LKIYFSSRTH | SQLTQFASQL | TLPSFPPSSP | TLEKERIKFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PLASRKQLCI | HAKVSKLKSD | LINDACVETV | KRQECQFYTN | SRDLISSKQF | RDYTFSEISD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IEDLVQLGHS | LHVCPYYSSR | TALEGAEIVT | LPYQHILSFE | IRESLGINLK | DSIVIIDEAH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLMDTITSIY | SCEISLSDIK | ICKKLMKIYL | NKFKRKLNGK | NRVNIMKLMK | LLDILQAFIE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SHFEKGKEIS | PQSMFRDSNA | DLLNIHELVT | YMRGSKIAYK | IDSYADSKLK | SDESNTNSVK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPILFKISKF | VLSLSNPSFE | GSFFFEEGMI | IKYMLLEPNQ | IFKTIVNDSK | CVILAGGTMQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PTSEFIENLL | PFVPSKDIVQ | FSCNHIIPES | NLDTFIVSEG | FNFNYESRNN | ESVMCKLYDF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LLELGCRVPH | GIVVFFPSYG | YLEHVIKFWQ | LEEIFEKLSM | NKRIFYETPG | GSDILPQYSS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TILDKKKGAF | LFSVVGGKLS | EGINFQDNLA | RAVVMVGLPY | PNLYSSELLV | KKRHIEQKVI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SAGGSLKDAK | SATIEFYENI | CMKAVNQSIG | RAIRHANDYA | CIYLVDNRYL | NNKVQHKLSE |
| 790 | 800 | ||||
| WVRKRVKSEL | KTSEIFAQTS | VFFASNR |