Q6CI08

PR
Gene name
TIF34
Protein name
Eukaryotic translation initiation factor 3 subunit I
Names
eIF3i, Eukaryotic translation initiation factor 3 39 kDa subunit homolog, eIF-3 39 kDa subunit homolog
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0A02695g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

105-261 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CI08

Entry ID Method Resolution Chain Position Source
AF-Q6CI08-F1 Predicted AlphaFoldDB

No variants for Q6CI08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CI08

No associated diseases with Q6CI08

5 regional properties for Q6CI08

Type Name Position InterPro Accession
repeat WD40 repeat 1 - 126 IPR001680-1
repeat WD40 repeat 136 - 177 IPR001680-2
repeat WD40 repeat 180 - 221 IPR001680-3
repeat WD40 repeat 279 - 318 IPR001680-4
conserved_site WD40 repeat, conserved site 67 - 81 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRPILLQGHE RPLTQLKYNR EGDLLFSVAR DKTICVWYSH NGERLGTLEG SGGANFSVDA
70 80 90 100 110 120
DPTTTIVATG SADQTARLWD IKTGKTIHSW NFKTTVKRVE FSPDGTKLIV LSEKMMGYPG
130 140 150 160 170 180
GISVFNVKAD VNATQETEPI MDIKPEEGAD KFSFAVWSYG GKYIITAHAD GSLSKYDGAT
190 200 210 220 230 240
GEFIASTQIH EEKFPITDLQ PSPDKTYVIT SSKDKTARLT DVDSLKLLKT YKTDTSMNSA
250 260 270 280 290 300
CITSKKDFVI LGGGQDAKDV TTTSSRDGKF EARFYHKIFE DEVGRVKGHF GPLNCVVAHP
310 320 330
NGGSYASGGE EGYIRIHHFD PSYFDFTYDV ERFAAKE