Q6CEK8
Gene name |
SET1 (YALI0B14883g) |
Protein name |
Histone-lysine N-methyltransferase, H3 lysine-4 specific |
Names |
COMPASS component SET1, SET domain-containing protein 1 |
Species |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
KEGG Pathway |
yli:YALI0B14883g |
EC number |
2.1.1.354: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CEK8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CEK8-F1 | Predicted | AlphaFoldDB |
No variants for Q6CEK8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CEK8 | |||||
No associated diseases with Q6CEK8
6 regional properties for Q6CEK8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 403 - 489 | IPR000504-1 |
| domain | RNA recognition motif domain | 550 - 617 | IPR000504-2 |
| domain | SET domain | 1029 - 1152 | IPR001214 |
| domain | Post-SET domain | 1154 - 1170 | IPR003616 |
| domain | Histone lysine methyltransferase SET associated | 552 - 616 | IPR024636 |
| domain | COMPASS complex Set1 subunit, N-SET domain | 870 - 1023 | IPR024657 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.354 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| Set1C/COMPASS complex | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone methyltransferase activity (H3-K4 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| histone H3-K4 methylation | The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANGSDTKPV | PKGPRGARAD | DTRTPPHPDR | RGSDRDQYFS | KDRSYGGRTD | RDYSDYDRAY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPPRDYDRYG | GGKYGKYDKY | DKYDRYDRLD | SHDYPPRRDR | DYDRSRDARD | TDSRDYGRLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRDTRPPPRG | GREYRYARDE | RGWDRDRRDL | DRDRDRDPRD | RERDARDRDR | DRDFRDRDHD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRDRDPKGYR | PHSLDPLPSR | DRDMPPRERE | RELVRERDLF | SRDRDLITGV | RELARSPPPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRDGRNRDRS | NDRHDRSFDK | HTRDRGTRDR | DTKEKGSVIS | TPQTAPTPRL | TPTNGKPDLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TSQPPAPPSP | PRLKTFPKEV | WETVGRKNNT | RLTYDPELSK | DKQKGKRGIY | EEVKKGASTT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDPRSKHPHY | FKTSSKSNKK | PYQRLPVPRF | LYDANSIAPP | PSTQIIVKGL | SSLTTSKTIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AHFKTYGELE | AVNMVEDPAT | GSSVGACLVR | FKVTKNNYEA | AHECLKKAIR | GQKTGRIDQA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KYRVEPDEDG | AKAKDIIKRV | AARAAKKAMP | VKQPPTAPAA | DKSIMEKLPT | PVPSARPSPK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AAQLMKTSAY | IFIAGKYLPS | EKVFASDIRR | ILRDFGWFDV | LKEGDGFYVF | FDNNRDTVEC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YEAMNGRKVN | GHQMAMAMIR | LSRVAPKTKE | SEENATEQAP | KLPPKEEARK | LIVQELANSL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RKDIRERVIA | AAIVEFLNPA | RFTHIKQDPE | PSAATEPNTV | NASAARVDTP | EPVQSSSAIP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GFLPRFKIKR | KGDPTKKKDA | TKKNRKKISA | RPMNHVLNDY | YSDEEDSTRM | STPIVPDTSA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DAAELPIRKP | RKKISQSKQR | IMDFSSSEGS | NESEEEEEVE | DDMEEEEDET | AQEELQEAST |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LDTSQQLTTA | FGEILDWAPA | HGFPQPVTAD | KKGGALTTIS | GFQALVKDDE | DMELLQEALE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GIEPEKINGE | AWTWTHKHLN | EAVAKENAEF | PELAAPNAFV | NSTGSWKSQG | YFKIPEAAKS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EYLPHRKKLN | IPIDTLQMEN | REKKKENASN | SRVNRANNRR | LVADINMQKQ | LLSTETDVLN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FNQLRKRKKP | VKFARSAIHN | WGLYAIEPIA | ANEMIIEYVG | EVVRQEIADL | REARYMRSGI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GSSYLFRVDE | STVVDATKRG | GIARFINHCC | TPSCTAKIIK | VEGQKRIVIY | ASRDIAANEE |
| 1150 | 1160 | ||||
| LTYDYKFEKE | IGEERIPCLC | GAPGCKGYLN |