Q6CCB0

PR
Gene name
SSN3 (CDK8, YALI0C10967g)
Protein name
Serine/threonine-protein kinase SSN3
Names
Cyclin-dependent kinase 8
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0C10967g
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

190-216 (Activation loop from InterPro)

Target domain

40-350 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6CCB0

Entry ID Method Resolution Chain Position Source
AF-Q6CCB0-F1 Predicted AlphaFoldDB

No variants for Q6CCB0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CCB0

No associated diseases with Q6CCB0

2 regional properties for Q6CCB0

Type Name Position InterPro Accession
domain Protein kinase domain 40 - 350 IPR000719
active_site Serine/threonine-protein kinase, active site 169 - 181 IPR008271

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNYRRGVGS YSRMLGGGTN PFAAYTARKA KTKKRVLDKY EIIGYIAAGT YGRVYKARSK
70 80 90 100 110 120
DPGDTNQYAI KKFKADKEGE MVHYAGISQS ACREVALCAE LDNRNITKLV ETILEDTCIY
130 140 150 160 170 180
MVFEYAEHDL LQIIHYHSHP ERKPIPEYTL KSILWQLLNG VSYLHQNWVL HRDLKPANTM
190 200 210 220 230 240
VTSDGVLKIG DLGLARLFSN PLQSLYSGDK VVVTIWYRAP ELLLGARHYS PAVDLWAVGC
250 260 270 280 290 300
IFAELLALRP IFKGEEAKMD NKTNVPFQRN QMQKIIEILG SPQEDDWPSL SKFPEYESLK
310 320 330 340 350 360
QMKTFPPNLE AWYQSIGGTN QKGFQLLSRL LEYDPAKRLT ANDALLHPYF TEAPKVSQNV
370 380 390 400
FERQEYKYPP RRISCEDSDI KTMTYQGTKR GSQGGDNLHP RKKQK