Q6CBH3
Gene name |
COQ1 (YALI0C18755g) |
Protein name |
Probable hexaprenyl pyrophosphate synthase, mitochondrial |
Names |
HPS |
Species |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
KEGG Pathway |
yli:YALI0C18755g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CBH3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CBH3-F1 | Predicted | AlphaFoldDB |
No variants for Q6CBH3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CBH3 | |||||
No associated diseases with Q6CBH3
2 regional properties for Q6CBH3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Polyprenyl synthetase, conserved site | 208 - 222 | IPR033749-1 |
| conserved_site | Polyprenyl synthetase, conserved site | 336 - 348 | IPR033749-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| decaprenyl diphosphate synthase complex | A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. |
| extrinsic component of mitochondrial inner membrane | The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| transferase complex | A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| di-trans,poly-cis-decaprenylcistransferase activity | Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate. |
| metal ion binding | Binding to a metal ion. |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
| trans-hexaprenyltranstransferase activity | Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| farnesyl diphosphate biosynthetic process, mevalonate pathway | The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols. |
| isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
| ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRVGRIGTK | TLASSSLRFV | AGARPKSTLT | EAVLETTGLL | KTTPQNPEWS | GAVKQASRLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETDTPIRDPF | SIVSQEMSTL | ANNIGSLIGS | GHPTLNKVAT | YYFQSEGKHV | RPLIVLLLSR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALSAIPESER | DRGTFDASDV | TENVGELNPE | PSINDPLSPI | EILHGINPDI | VLNPLSRPSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLPYESNGIL | PKQRRLAEIV | EMIHTASLLH | DDVIDNSATR | RGSPTGNVAF | GNKMAILAGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLLGRASVAI | ARLRNAEVIE | LLSTTIANLV | EGEFMQLKNT | IVDNSEIANK | ATFEYYIHKT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLKTASLMSK | SCRAAAVLSG | ARNPIVDASY | KFGKNLGLCF | QVVDDMLDYS | EGESHLGKPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GADLKLGLAT | APVLFAWEKY | PELGDMIKRK | FDGPGDVERA | RFLVQQADGL | SRTRELAQKY |
| 430 | 440 | 450 | |||
| CDEAVANLDL | LPYSESREAL | RNLTMKMMNR | SK |