Q6CAX5

PR
Gene name
PNG1 (YALI0C23562g)
Protein name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Names
PNGase, Peptide:N-glycanase 1
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0C23562g
EC number
3.5.1.52: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6CAX5

Entry ID Method Resolution Chain Position Source
AF-Q6CAX5-F1 Predicted AlphaFoldDB

No variants for Q6CAX5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6CAX5

No associated diseases with Q6CAX5

1 regional properties for Q6CAX5

Type Name Position InterPro Accession
domain Transglutaminase-like 145 - 236 IPR002931

Functions

Description
EC Number 3.5.1.52 In linear amides
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.

3 GO annotations of biological process

Name Definition
glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
protein deglycosylation The removal of sugar residues from a glycosylated protein.
protein quality control for misfolded or incompletely synthesized proteins The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQATFAKEL TAKFAQLWTE KTKRPLPPVN QAMMQRLRQG QRQSGPNEVF SRVSALFRDL
70 80 90 100 110 120
SLIPQSFENA ELQDMAMEIL PLDRLYSVAE ERAEEEGERD NWGLQDYLIM ELLRWFKQDY
130 140 150 160 170 180
FTWVNSPPCE TCGENGNVQF VRRENSTPEE QKYDASGTEV HQCSNCNTEI RFPRYNDLSK
190 200 210 220 230 240
LMETRRGRCG EWAKCFAFFC RALGLRTRYI WNAEDHVWSE VYSERRKEWI HTDSCEEAWN
250 260 270 280 290 300
SPTIYSQGWG KKMSYVVGFS GDGVTDVTRR YVRKADQQLP RTMVPDEQFK TILNSITSDI
310 320 330 340 350
RQNLSPSEKE ELKREDEAEE RELASYNADE PQEAQMPRQS GSVEWTKARG EGGSDD