Q6CAX3
Gene name |
CHL1 (YALI0C23639g) |
Protein name |
ATP-dependent DNA helicase CHL1 |
Names |
Chromosome loss protein 1 |
Species |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
KEGG Pathway |
yli:YALI0C23639g |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6CAX3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6CAX3-F1 | Predicted | AlphaFoldDB |
No variants for Q6CAX3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6CAX3 | |||||
No associated diseases with Q6CAX3
5 regional properties for Q6CAX3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | 325 - 334 | IPR002464 |
| domain | Helicase-like, DEXD box c2 type | 7 - 375 | IPR006554 |
| domain | ATP-dependent helicase, C-terminal | 585 - 779 | IPR006555 |
| domain | RAD3-like helicase, DEAD | 172 - 351 | IPR010614 |
| domain | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | 5 - 388 | IPR014013 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA duplex unwinding | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. |
| DNA-templated DNA replication maintenance of fidelity | A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. |
| establishment of sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MENTKRREFS | HPYTPYPIQV | DFMEALYDCI | ESYKVGIFES | PTGTGKTLSL | ICGSMTWLRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NKAQLAVSTA | SADENEPAWV | LEQTIQLARE | EFSRNREMLQ | KRLDKMRRKN | MRARISYEQG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKRAKKAPEP | VDDSQFLPED | YSEVIKPEVQ | RLLSALAPPV | ENDFQEPVKI | IFASRTHSQL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQFVGQMQHT | TFPPSSDLQD | LESTKLISLG | SRKQLCINPR | VSHMNSVQAM | NDACRDLREG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKGGCKYYKN | PHDALGKVDI | NTFRDTTLAE | ILDIEDLYKL | GKHTSTCPYY | ASRASIPASE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VITVPYQILL | SRSARKAIDL | PVKNSIVIID | EAHNLLDTIT | SLHTMSITKS | QVSSASSGLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KYQHKFQNRL | NSGNRVNLGY | LVNMLQALEV | FFEKAQKFHK | KETAPGTPVT | TSSLFDGSTA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLINVNRLEK | YIDESKIVFK | IESYLEHVNG | ETQEKSHSSS | LVLSSVMEFL | RQVNNPDSEG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VLCFDGPTKL | KYQLLDPSEP | FKDIVENARC | VVLAGGTMEP | TGDYLEYLLP | YLSQDQIKLF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SCGHVIPPQN | LSVQVIPNGP | NYSFNFTFDK | RNDEKMILDV | AITLLVYSKI | IPEGMVVFFP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SYKYLEQVVA | VWKKAKKDGK | NIYEILNDQK | RIFVESQHDS | VEKTLSEYAE | EVPKGAILLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VVGGKMSEGI | NFSDGLARAV | FMIGLPFPNL | MSAEIIAKRK | YIEQSVSEKM | KAKGVSAKEA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LEASKGAARD | FYMNICLRAV | NQSVGRAIRH | ANDYACIFLL | DGRFGKPEIQ | KKLSKWMREG |
| 790 | 800 | ||||
| IREGSFKEAL | GEVQQFFASH | EKN |