Q6C9T3

PR
Gene name
ALG11 (YALI0D08558g)
Protein name
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Names
Alpha-1,2-mannosyltransferase ALG11, Asparagine-linked glycosylation protein 11, Glycolipid 2-alpha-mannosyltransferase
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0D08558g
EC number
2.4.1.131: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

80-158 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6C9T3

Entry ID Method Resolution Chain Position Source
AF-Q6C9T3-F1 Predicted AlphaFoldDB

No variants for Q6C9T3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6C9T3

No associated diseases with Q6C9T3

4 regional properties for Q6C9T3

Type Name Position InterPro Accession
domain FAD-binding 8 242 - 312 IPR013112
domain Ferric reductase, NAD binding domain 339 - 496 IPR013121
domain Ferric reductase transmembrane component-like domain 94 - 206 IPR013130
domain FAD-binding domain, ferredoxin reductase-type 230 - 355 IPR017927

Functions

Description
EC Number 2.4.1.131 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

1 GO annotations of molecular function

Name Definition
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

3 GO annotations of biological process

Name Definition
dolichol-linked oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.
oligosaccharide-lipid intermediate biosynthetic process The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.
protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALQLDLPTL HDLRVVLNAD FLAALAALLL LAVILVPLCS YISLYAWSAI LAFKLRSPPA
70 80 90 100 110 120
NWEKSIVKGV QANGTSTLFG FGFWQAAAVR RQLILQSNDP SYYSVTHVSR RSEIAISPED
130 140 150 160 170 180
RNTEFRNRAQ DSGAPRRVIY GFFHPYANAG GGGERVLWAA VKDTLMYDDN IICAIYCGEQ
190 200 210 220 230 240
DLPTRTSPST VLDAAVSNFH VTELADKELR KRIVFIGMRG RRLVDPKTWP RFTLMMQAAG
250 260 270 280 290 300
SVWMAWHGIS TLVPDVFVDT MGYPFAYPLV SWVTHVPVAA YVHYPVISKD MLATVSLKQS
310 320 330 340 350 360
PVRAALAVAK LVYWRVFALT YTFAGSYCSV VMTNSSWTNN HMQHMWWYNH KAEHIKIVYP
370 380 390 400 410 420
PCGTQALSEI AMSEETSARS PNIVYIAQFR PEKRHDIVLR EFNKFYKEYT EKYPNQPAPH
430 440 450 460 470 480
LTFVGTVRND DDKSRVYLLR LQARDLVNPD SVSFVLDAPF DKVRDILRTA SMGVNAMWNE
490 500 510 520 530 540
HFGIVVVEYM SAGLIPVVHN SGGPKCDIVV PYEGQSTGNS GTLSAMPSST SIRSHYEAVP
550 560 570 580 590 600
PGPTGFHFNC PGSDPTTDSG PSYDGEPIGT LAETLMRAFE LSESDTHNMR ARARESVKKR
610 620 630
FSNEQFGSHW QVRMRILEKL EQIRRGHRLT RGDFD