Q6C9N0
Gene name |
DSE1 (YALI0D09823g) |
Protein name |
Protein DSE1 |
Names |
Daughter-specific expression protein 1 |
Species |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
KEGG Pathway |
yli:YALI0D09823g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6C9N0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6C9N0-F1 | Predicted | AlphaFoldDB |
No variants for Q6C9N0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6C9N0 | |||||
1 associated diseases with Q6C9N0
[MIM: 618254]: Ciliary dyskinesia, primary, 39 (CILD39)
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Some patients exhibit randomization of left-right body asymmetry and situs inversus. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD39 inheritance is autosomal recessive. {ECO:0000269|PubMed:30388400}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Some patients exhibit randomization of left-right body asymmetry and situs inversus. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD39 inheritance is autosomal recessive. {ECO:0000269|PubMed:30388400}. Note=The disease is caused by variants affecting the gene represented in this entry.
4 regional properties for Q6C9N0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Oxoglutarate/iron-dependent dioxygenase | 165 - 275 | IPR005123 |
| domain | Prolyl 4-hydroxylase, alpha subunit | 78 - 274 | IPR006620 |
| domain | Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain | 304 - 535 | IPR019601 |
| domain | Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain | 172 - 274 | IPR039558 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Rpd3L complex | A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae). |
| Rpd3L-Expanded complex | A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cell wall organization | A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDALVNSFED | LNTSHTTSRY | RAKRHHARTK | SSPGSIKRNQ | SIRRHSRTLS | THYDSSNPYQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DASTSYAQLS | MGRRTEGSST | KPRPKSYVEP | SHTQTQAHYA | TDSHHPSHSR | SHSQTGHGPR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATFRHHHHRS | KSHTNPRSRF | ELRPQSHHET | YTYLPDDPSP | QFDEPNFSWM | EEAENQLSEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSKYKPEPMA | ASTSLSWQIP | DESHHLTSVA | VHESSPLIAV | GSGGKENNLF | VYETTQDKGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IHHQTISLPA | IHGLKWLSPS | QQVADLGNIL | ATSHSNGLAH | LVLLPDCYSS | DPAEILKRFN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HKHHVSIKDT | LSTRIKHLEL | TTPAWRSSVS | SSLATLYSQH | LFLWDPSRGD | TPVLTRKVKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEAFSLSPFQ | DGQVAAACGK | YTSLLDLRAK | SGSVNLLAGN | TNLCAYSPMN | SNLLATAHSD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSGLQENCVR | IWDSRHTAGP | LHKLEGHTDQ | IRSLEWSKFN | PCELHTSSND | GSLRLWNIGR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QQETKARPSL | EVYSGDLAAQ | WDEQKASAQW | LPRSARQMQQ | RGLAFNVAPL | NIQKKEKKEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KPALYSSSVI | AKTPHAAVAS | ASFMPTGSMH | PSVVTVDSYG | SLGIHSMPSA | TPYNTEPETP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RTLTARMSVQ | SFASTDMSSD | FTEADMSSAS | DTSPMTSPSM | ASAATFQSSY | DSPVKACIPE |
| 670 | 680 | 690 | 700 | 710 | |
| ARPATYETSV | SSSFIPPLQI | KKRVPSGPRP | EGSHVRRPSR | ESRNMLPELD | LDFDFGLTA |