Q6C783
Gene name |
CEG1 (YALI0E02904g) |
Protein name |
mRNA-capping enzyme subunit alpha |
Names |
GTP--RNA guanylyltransferase, GTase, mRNA guanylyltransferase |
Species |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) |
KEGG Pathway |
yli:YALI0E02904g |
EC number |
2.7.7.50: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6C783
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6C783-F1 | Predicted | AlphaFoldDB |
No variants for Q6C783
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6C783 | |||||
No associated diseases with Q6C783
No regional properties for Q6C783
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6C783 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.50 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mRNA cap methyltransferase complex | A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| mRNA guanylyltransferase activity | Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. |
| RNA polymerase II C-terminal domain binding | Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGIVPEIPG | EQAPPDAAHQ | LKVDVARLLQ | KPKLNFPGAQ | PVSFARKHIE | EELFKRDYYV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CEKSDGLRCL | MYVTWENNPD | TGPQQVTYLI | TRNNEFFFIP | MVHFPSNDGK | PLQDTIVDGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVLTKAEPRS | LHFLMFDCLA | CNKILLTGRP | LDKRLGYLNA | AISHPLKEYL | HKNPEVARDF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PFSVRVKDMQ | FAYNVMNVFA | SFPHLPHITD | GLIFTCRDHP | YVSGTDERIL | KWKKQDENSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DFLMTMKFPI | FEDTNGESWT | DYDAKPEITL | LVWTGRDGSR | PYGELYLTDE | EWDNLKALEE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PLEERVVECI | KDDKKRWRYL | RFRDDKTNAN | YITTVEKVID | SIDDPVSEKN | LLDAAPKIKE |
| 370 | 380 | 390 | |||
| LWKERNRRPR | DEDRKRVGGD | DHDHGAKRAR | Q |