Q6C3P4

PR
Gene name
PPM2 (TYW4, YALI0E33209g)
Protein name
tRNA wybutosine-synthesizing protein 4
Names
tRNA-yW synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0E33209g
EC number
2.1.1.290: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6C3P4

Entry ID Method Resolution Chain Position Source
AF-Q6C3P4-F1 Predicted AlphaFoldDB

No variants for Q6C3P4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6C3P4

No associated diseases with Q6C3P4

2 regional properties for Q6C3P4

Type Name Position InterPro Accession
domain JmjC domain 796 - 947 IPR003347
domain Cupin-like domain 8 708 - 933 IPR041667

Functions

Description
EC Number 2.1.1.290 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.

2 GO annotations of biological process

Name Definition
tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazopurine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNGVTNDKGH SDVTNTPESG ISTPKKKNPK SDKPVKVKNP NNAASKAYTV DLKIQGTNNS
70 80 90 100 110 120
SIVSKRSVER LYKEKHDLEF FRHFVKKPQR RSPIINRGYW TRMEAMGYCI SAALAEKAPK
130 140 150 160 170 180
HVIVNLGCGY DPYPFQHLHK HGLTENLIFV DVDYPDLMQI KVDTIRRSDE LTKLVGEEKP
190 200 210 220 230 240
AAEIKDKSVL MQTGNYIALS CDLRDLEKFE FIFRNLDLIV EGDNNPLILF TAEVSVTYMF
250 260 270 280 290 300
QKDADNLLQW CASLPNSRFA LLEQIIPAGT EHPFAKTMLA HFDSLQTTLW SVKKYPSIPA
310 320 330 340 350 360
QYERFTCLGW KEVSGISLAQ FWDSYVPDEK KEFVENVEAF DEWEEFLLFL NHYSIIYGGA
370 380 390 400 410 420
DIFQNSKSEY PEHEEFVLQC EKPTSEAHRI GAAACSFQNG VILNGGQAQN RESTSLLLSL
430 440 450 460 470 480
DSTDEFIVDK NNMIARQYHS LSEIEPGVVL LAGGRSSPTK KFSDCHILKN GLWKPTFDLP
490 500 510 520 530 540
EGRFRHCMQG TLLFGGSESK DQWLHFSPTA GWKALKCDFH YLTPYGATLI MKSPIEGILL
550 560 570 580 590 600
GGMDAKGNLG KEVYSVTISE GETVVLSLIP MKSPLIYARY GAQGVYHGNR YLLVGGVSYD
610 620 630 640 650 660
ILFNEHNQVV ELDIKKGNTI PVKLPFESYP LLVSHSVNIV RNCLVVAGGG AVCFSFGVFH
670 680 690 700 710 720
SDPEVVGNRE LKVIKEQRPS EEVKTEINST VISVEEGTLE SFPAAYVNAT PTIFRNCDIG
730 740 750 760 770 780
PSSELWKSHD YLKSNIGEDT KVSVHIADNK NLNFQSKNFS YQTLQFGELM KLISDIEADS
790 800 810 820 830 840
ESSKSAYLRS LSLDNPKSEA TDLCKDFPGI ARDFKLPKEM ADFIGNKVFS TPLRISSSKT
850 860 870 880 890 900
QIWLHYDVTA NVLCQVTGSK RVRMYHPRDV VHLGFPAGES SSKIPNIFVH ESCAQAYEVV
910 920 930 940 950 960
MNPGDILFIP PMWLHAVEPQ TESISVNCFW KDLDGNKYSK TKDIYGNKDL ASYESGREGI
970 980
KKIADKFAGL PADIKEFYLR RLAEELKQM