Q6C3J2

PR
Gene name
IPL1 (YALI0E34375g)
Protein name
Spindle assembly checkpoint kinase
Names
Aurora kinase
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0E34375g
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

239-260 (Activation loop from InterPro)

Target domain

99-350 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6C3J2

Entry ID Method Resolution Chain Position Source
AF-Q6C3J2-F1 Predicted AlphaFoldDB

No variants for Q6C3J2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6C3J2

No associated diseases with Q6C3J2

3 regional properties for Q6C3J2

Type Name Position InterPro Accession
domain Protein kinase domain 99 - 350 IPR000719
active_site Serine/threonine-protein kinase, active site 218 - 230 IPR008271
binding_site Protein kinase, ATP binding site 105 - 128 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Chromosome, centromere, kinetochore
  • Associates with the mitotic spindle and on elongated and disassembling spindles
  • Also associated with the kinetochore (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

4 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSMKQLETSM SSVSLQEKKP TRIKIALHPQ SKSEQNETDR ASKIPTGRIS TTQPQTYYRP
70 80 90 100 110 120
TNLTKTPASQ VSRRSSYTTD PPSPLTGITG FRNYSLDDFE IGKALGKGKF GKVYLVKDKK
130 140 150 160 170 180
TGFVSALKCM EKKELVEGNV EKQFRREVEI QSNLRHTNVL RLFGHFHDKD RVYLILEYVV
190 200 210 220 230 240
HGELYKLLRN QKRFTESTAS SYIYQMSEAL LYLHGKNIIH RDIKPENILL HFNDTIKISD
250 260 270 280 290 300
FGWSVHAPSN RRSTLCGTMD YLPPEIVQSR PYDKNVDVWS LGILMYEFLC GAPPFEEPGG
310 320 330 340 350 360
AQATYRRIVK LDLRIPPYVS ADAADLIKRM LTLDPAKRFK LKDMHKHPWI VRLRPTWKYK
370
VPKTASHERS A