Q6C354

PR
Gene name
PDH1
Protein name
2-methylcitrate dehydratase, mitochondrial
Names
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0F02497g
EC number
4.2.1.79: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6C354

Entry ID Method Resolution Chain Position Source
AF-Q6C354-F1 Predicted AlphaFoldDB

No variants for Q6C354

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6C354

No associated diseases with Q6C354

2 regional properties for Q6C354

Type Name Position InterPro Accession
domain MmgE/PrpD, N-terminal 53 - 307 IPR045336
domain MmgE/PrpD, C-terminal 324 - 499 IPR045337

Functions

Description
EC Number 4.2.1.79 Hydro-lyases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
2-methylcitrate dehydratase activity Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O.

1 GO annotations of biological process

Name Definition
propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRAFRSAANF GAASNIYRKS FTPASIASNR FVSARMSSIM TDNARPNTDK VVQDIADYIH
70 80 90 100 110 120
DYKIDSSVAM ETARLCFLDT LGCGLEGLKY QQCANIVGPV VPGTIVPNGT KVPGTDYQVD
130 140 150 160 170 180
PVRGAFNIGT IIRWLDFNDC WLAAEWGHPS DNLGGILAVA DWQTRSAKAG LEGKVFKVKD
190 200 210 220 230 240
VLEGMIKAHE IQGGLAIENS FNRVGLDHVV LVKIASTAVV SGMLGLSREQ TADAISQAFV
250 260 270 280 290 300
DGQSLRTYRH APNTMSRKSW AAGDATSRAV NLALLVKKGE GGMPSILTAK TWGFYDVLFG
310 320 330 340 350 360
GKEFKFQRPY GSYVMENVLF KISFPAEFHA QTACESAMLL HEELKKLGKT SDDIASIKIR
370 380 390 400 410 420
TQEAAMRIID KKGPLHNYAD RDHCIQYMVA IPLIHGRLTA DDYTDEIASD PRIDALREKM
430 440 450 460 470 480
ECVEDKRFSE EYHAPDKRYI GNAIEITLKD GTVLDEIEVN YPIGHRQRRE EGTPVLLEKF
490 500 510
ARHLRGRFPE GQVEKILAAS NQDIVNMDID EYVDLYVKKD