Q6C2F5

PR
Gene name
ATG9
Protein name
Autophagy-related protein 9
Names
Species
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KEGG Pathway
yli:YALI0F08349g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-158 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6C2F5

Entry ID Method Resolution Chain Position Source
AF-Q6C2F5-F1 Predicted AlphaFoldDB

No variants for Q6C2F5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6C2F5

No associated diseases with Q6C2F5

1 regional properties for Q6C2F5

Type Name Position InterPro Accession
binding_site EF-Hand 1, calcium-binding site 20 - 32 IPR018247

Functions

Description
EC Number
Subcellular Localization
  • Preautophagosomal structure membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle membrane ; Multi-pass membrane protein
  • Golgi apparatus membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
phagophore A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle.
phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

1 GO annotations of molecular function

Name Definition
phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.

6 GO annotations of biological process

Name Definition
autophagy of mitochondrion The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
cytoplasm to vacuole transport by the Cvt pathway A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.
late nucleophagy A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM.
piecemeal microautophagy of the nucleus Degradation of a cell nucleus by lysosomal microautophagy.
protein localization to phagophore assembly site Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS).
reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDKSTFLSV LFGGGSVYQD LDGDGEVEDA EILRRVEEEH AQTSDNSNSD NDSGNDSDVP
70 80 90 100 110 120
TSLMVEGVQD PKPGSKRRQP HRMATLSNLQ SSAGPGARSV SFAQGTKTQT PIRLTKPTGV
130 140 150 160 170 180
ANGGLPRHKQ DLGASIRTMV DPKELALWKW ANVQNLDNFF AEAYMYYTGK GLVSIILSRV
190 200 210 220 230 240
LNMSTIMFVV VFSTYLGSCI DYSKIKGSRT LDEVHVKQCY AKLGSFHVFV LWTFFVLWFM
250 260 270 280 290 300
KLFQYVKDIR RLVDMKSFYQ ELLEIDENEL QTISWPQVAK RMATLSEANA ATQVGNSTKQ
310 320 330 340 350 360
RIEPHDIANR VMRKENYLVA MFHKRVLNMT VPLPQPLQRI FGRPQLLSRA LEWNLSLCIL
370 380 390 400 410 420
DYVFNPAGQV RPMFLKSTHK QILSTGLRRR FVFAAIMNVV FAPFIILYLA LLYFFRYFNE
430 440 450 460 470 480
YHKNPASIGT RRYNPLAEWK LREYNELPHQ FERRLTLSYI PASKYLDQFP KEKTALVSKF
490 500 510 520 530 540
VSFIAGSFAA VLGIASLIDP ELFLMFEISA NRTVLFYIGV FGSILAVSRS LIPEETLVFD
550 560 570 580 590 600
PEISLRYVAE FTHYLPPEWE GKLHTEQVKN EFSLMYEMRL IILLKELASI FLAPFILYYS
610 620 630 640 650 660
LTQSCDDIVD FIRDHSVHVD GLGYVCTFAM FDFKQKSPDH QPDEDQKMLK SYLYFMDHYG
670 680 690 700 710 720
DKPTNVSQTQ QNVPMYSSVR LKNDGLDLNN SIMQKFQKHN GHHALSGLTQ RDVGLSPAAP
730 740 750 760 770 780
TATTATSGTA TGAAPRRDLI NFDVDESFID QTTSNRDMDN DEQPKDKERV VDMLNQFYKK
TDNMNLGA