Q6BZ78

PR
Gene name
PAN2
Protein name
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2A03388g
EC number
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

415-497 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BZ78

Entry ID Method Resolution Chain Position Source
AF-Q6BZ78-F1 Predicted AlphaFoldDB

No variants for Q6BZ78

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BZ78

No associated diseases with Q6BZ78

3 regional properties for Q6BZ78

Type Name Position InterPro Accession
domain Exonuclease, RNase T/DNA polymerase III 915 - 1100 IPR013520
domain PAN2, UCH domain 514 - 835 IPR028881
domain Ubiquitin specific protease domain 514 - 861 IPR028889

Functions

Description
EC Number 3.1.13.4 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

2 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGWGEISRI AATASSSVID NSKITSLQFD NQQNLLWCGD SKGTTRSFTP QSTSIPMPYP
70 80 90 100 110 120
ALHLSQYSKF KTSLGTSPVK QYLNHQKGIL SLSHNCVNFN NRRGLTQLSL NSESLKEPGF
130 140 150 160 170 180
NNLSCMTFNS NTNNDLVIAG DSLFKVDLLK PNMTTSFNHT GKVSMIDNTL NYLTLGKSNG
190 200 210 220 230 240
EIEIFDPVSN QTVKSFYGHN GLLSDIDVQG NYVASCGYSL RPRRNQASQS SYMIDPLVNI
250 260 270 280 290 300
YDLRMMRSLP PIPFSAGASF VKFHPKLPNI MIIASSLGQL QFVDIYDQSN VYLYQADLSN
310 320 330 340 350 360
VNASTPTTSS NTYLANLEVS GNGEFITFSD GFQNLHLWSF KNNNSKNFIN FPSYLEQPDF
370 380 390 400 410 420
SPPFQQNHIN VDDVVPLSSI GMPYYKDLLL SNYASDLHFT KELSKLPNHL DPELLQNQYS
430 440 450 460 470 480
QVLPYNTLKY GKRNLNKFYV PLQNNVSTKQ KLFPKFISEK NGHDSFDNEN SNIFEYKLSN
490 500 510 520 530 540
KFEVPNCYSN LKIQYSKFGV EDFDFSFYNR TKYSGLENHL DNSYINSLLQ LYKYSPVFQN
550 560 570 580 590 600
FIIKHLLKEW LPNDLTTIIQ NGNPQGSSIL NELGYIFDMM NKSHGKNCKT SNFSNVLSQN
610 620 630 640 650 660
QVAQMQELIN KDDCKNLNAF EIRAIIGKFN KFLLSTCNND LLNQFNTSLS EITNIGYEIE
670 680 690 700 710 720
IKSNGCNINN VNYNSQLTVD LMSPPINKLS ILISANSTSA TKKNLNILNY LDYSMNQFKT
730 740 750 760 770 780
IKCQQCNNSF PHLLEIRQSL VHLPPVISIN VNFTGQEFNL IQNFPNWLVP EFYTYGMNNK
790 800 810 820 830 840
VSFKLHSNDN LSNKYELLGY VCEINVGSEF LKGKHNLVSY IKIESKWYLF NDFLVMPIPE
850 860 870 880 890 900
SEVFDLSYHW KKPIIVMYQL ANHADFGSFQ QQSFAQLPDL NDSILYRDHF AGGIRDSIKR
910 920 930 940 950 960
EYELLTKDEA PNAGTLIAID AEFVALNPEE LEVHYGGVRN LIKPRNLSLA RISVLRGDNG
970 980 990 1000 1010 1020
PKQGVPFIDD YIIHTCFIDD YLTSFSGIEP GDLDPSSSTK TLTTLQTSYR KLWLLLNLGC
1030 1040 1050 1060 1070 1080
IFVGHGLQND FRCINLHVPK NQIRDTADFF YLPELKRKLS LKFLAYILLK EKVQTGNHDS
1090 1100 1110 1120
IEDANTALLL YKKYLELTAI GEFESTLHRI YMDGQQLRFR VPDS