Q6BY28

PR
Gene name
CHO2 (DEHA2A12936g)
Protein name
Phosphatidylethanolamine N-methyltransferase
Names
PE methyltransferase, PEAMT, PEMT
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2A12936g
EC number
2.1.1.17: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

560-636 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BY28

Entry ID Method Resolution Chain Position Source
AF-Q6BY28-F1 Predicted AlphaFoldDB

No variants for Q6BY28

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BY28

No associated diseases with Q6BY28

2 regional properties for Q6BY28

Type Name Position InterPro Accession
domain 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal 197 - 274 IPR001104
domain SKICH domain 672 - 758 IPR041611

Functions

Description
EC Number 2.1.1.17 Methyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
phosphatidylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine.

2 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKETKVQNTI AGAKGITFSG DTFVVPETHD MVKTLFDPMV RKSYCEMIIL LILAANGLVF
70 80 90 100 110 120
WLINNNTLRI ETFIGLYIFW RLSYNFGIGY LLNVQSNHHR LVKWARKAQV FKKNGSLVSR
130 140 150 160 170 180
LAEKEIKSQM GPEYDVQKYP IEFNTWLLFR KVVDLILMSD FTTFICLVVV CAINKDYQFI
190 200 210 220 230 240
NSDQQEVWLI STRLILGTVL ILFNLWVKVN AHNTIKDYAW YWGDFFFRQI NNEDLIFDGV
250 260 270 280 290 300
FEMVPHPMYS VGYVGYYGFA IISKSYTILT VAIFGHFLQM IFLHYIENPH IDKIYGPSGN
310 320 330 340 350 360
EADIEMLLKL KDLRHFDNIK PLVGLLNFTW LRASDMTNLI MVGTYSFTIP YLASLVDTVR
370 380 390 400 410 420
VGETGVNPGT ILFILTIVIK VFESLSINIL LILQSYYKTF TKWYLSNDIS VEKTLNNWSI
430 440 450 460 470 480
MYNSLISLTY SSFFGLNFYH VLIGLESDKL FINSWVYLRI FLGILLVFTQ VWINSSIIDS
490 500 510 520 530 540
IGYFGWFYGD FFIPKTSQQK AHLTKAGVYR YLNNPEQIFG VCGIMGVTLI IPSLENLICC
550 560 570 580 590 600
VLWVTNNFIR INFIEKAHMI KIYGEREVMK DSGVTKTFKK HLIPGAIQRR LSKGSEDNSD
610 620 630 640 650 660
LLNQHRRKST IMAGATDSLD NFIKELKNTN TRLTKQNILE LSQNLYFENS DYKLVIKNLN
670 680 690 700 710 720
TTENNLSTAF IGEPIEVEWK APENHSPKDW IGLYKTVQTT YSRYKTLISS SDRWTQVTSD
730 740 750 760 770 780
SGSYVFEGEK LFWEEGIYEF RYHLDGKHDV AYISEPFELT SANIEVPPST EGSIVLANEL
790 800 810 820 830 840
KAKVFDRAIV GFGSIDSPID SAVQKSGSII QTYNRLAYVI SKSTGIHINA KVFLYADNED
850 860 870
ELTVHKLSLK LINIRKVLDD LSHAHYPLSE EKKEE