Q6BW21

PR
Gene name
DEHA2B14960g
Protein name
Leucine aminopeptidase 2
Names
Epoxide hydrolase, Leukotriene A-4 hydrolase homolog, LTA-4 hydrolase
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2B14960g
EC number
3.3.2.10: Ether hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BW21

Entry ID Method Resolution Chain Position Source
AF-Q6BW21-F1 Predicted AlphaFoldDB

No variants for Q6BW21

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BW21

No associated diseases with Q6BW21

3 regional properties for Q6BW21

Type Name Position InterPro Accession
domain Peptidase M1, membrane alanine aminopeptidase 235 - 451 IPR014782
domain Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal 483 - 638 IPR015211
domain Aminopeptidase N-like, N-terminal domain 34 - 204 IPR045357

Functions

Description
EC Number 3.3.2.10 Ether hydrolases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTLEYINKKR PSVSPELDPC SNSNYKDFQV SNTELDISVS FDKKIVSGQV TYKLTAKTPN
70 80 90 100 110 120
TTSIVLDTSY LKIIKIRING LPSDNYELVK RKEPFGSPLK ISLPTTINKE FELNIEFSTT
130 140 150 160 170 180
DKCTALQFIE KEATDGQTAP YLFSQCQAIH ARSLFPCFDT PGIKSPYNMK VKSPYACLMS
190 200 210 220 230 240
GRPKETNEEG VYCFHQPIPI PSYLVALASG DLASAPIGPR STVYSERVGL SDCQWEFEKD
250 260 270 280 290 300
MENFIQVAEG LIFKYEWLKF DALILPSSFP YGGMENPNIT FATPTLISKD RSQVKVMAHE
310 320 330 340 350 360
LAHSWSGNLV TNCSWEHFWL NEGWTVYLER RIIGGIAAAE AKSLGEKEAA QYGEKRRHFS
370 380 390 400 410 420
AIVGWNSLVD SVKTLDPKYT SLVWNLKEGS DPDDAFSRIP YEKGFNFLFY IEQQVGGIKE
430 440 450 460 470 480
FDPFIPYYFK KFRYESLDTY QFIDVLYEFF EPRGKAAKLD AIDWKGWIFG EGLPPNIPQF
490 500 510 520 530 540
DPSLADECYR LVDKWVDFAK SNSTDISGFN ESRDIGNFEP DQHKLFLESL TEKFGAYSVS
550 560 570 580 590 600
EQIIRKLPSI YPFYAASTNG EIKSSWNELL IRFGNYNTTD QIVQDFAMWL GTVGRMKFVR
610 620 630 640
PGYKLLQAYV SKEFAISTFT KFESSYHPIC KTMVKKDLSL I