Q6BS08

PR
Gene name
ATG1
Protein name
Serine/threonine-protein kinase ATG1
Names
Autophagy-related protein 1
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2D12452g
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

334-543 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

203-225 (Activation loop from InterPro)

Target domain

22-318 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6BS08

Entry ID Method Resolution Chain Position Source
AF-Q6BS08-F1 Predicted AlphaFoldDB

No variants for Q6BS08

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BS08

No associated diseases with Q6BS08

2 regional properties for Q6BS08

Type Name Position InterPro Accession
domain Activity-regulated cytoskeleton-associated protein, C-terminal domain 278 - 356 IPR040814
domain Activity-regulated cytoskeleton-associated protein, N-terminal domain 46 - 154 IPR045557

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Preautophagosomal structure membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
protein phosphorylation The process of introducing a phosphate group on to a protein.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTTSIESNN DIGRSVKTIG VYSIGPEIGK GSFATVYKCF NTKTNESVAI KSVVRSKLKS
70 80 90 100 110 120
KKLVENLEIE ISILKTMKHP HIVGLLDYKQ TTSHFHLVMD YCSMGDLSYF IRKRNQLIKT
130 140 150 160 170 180
HPVISSLLER YPSPEGSHGL NEVLVIHFLK QLVSALEFLR NKSLVHRDIK PQNLLLCPPL
190 200 210 220 230 240
HSKQEFKDGG FVGLWELPLL KIADFGFARF LPSTSMAETL CGSPLYMAPE ILRYEKYNAK
250 260 270 280 290 300
ADLWSVGAVL YEMTVGKPPF RADNHVQLLK NIEKSNDRIK FPSAAQVPES LKRLIRSLLK
310 320 330 340 350 360
YNPTERVSFN EFFNDPLIVN DLEGNDEPLE TSEMDENLFI SEYISPIKSS QKSQYIEPIT
370 380 390 400 410 420
TEVAVKEKSK QDLPAREVST HASESQTKAV DTRPSSRDEE IKEIINKNSP GPETSRSIQP
430 440 450 460 470 480
HNLKEKSLVL KNKDNDIILE RDYVVVEKRA VEVNAIADEL AHAGSGAVAI NPRRTSSGSD
490 500 510 520 530 540
NSYNGPNNMQ LYRRPSLRSN SSGSQRRPSF TDRRISISIS PTNALTKAIG LASNRLFGVN
550 560 570 580 590 600
ASGSPTNRLI EETDERLAIN ENNSSMNATN NTFSTILSNP NFANNLLIQK LNLPTSATVA
610 620 630 640 650 660
NNSQTNTSPQ LSPQSKTDES VLNRLESLAT KAHAINLFAD VKFSQLIPSP PSSDALDDDL
670 680 690 700 710 720
LHQNDMLPPK IVKSISEEGV VLYVKTLSLL AKGMVIASDW WYSQFEIDDP SNKNSNENPL
730 740 750 760 770 780
KQSSNNNSDD LSLAVRINEL VQWIREKFNE CLEKAEFIRL TLQEANTLLS NEDSSEYMGN
790 800 810 820 830 840
SNSVADKTRV VAEKLIFDRA LEMSRNAAVN ELVKEDLKGC ELAYSTAIWM LEALLDEDSS
850 860 870
NDEDRLDDED KAMVEKFIVS IGNRLSVLKR KLEVV