Q6BRY4

PR
Gene name
ICL1
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratase, Methylisocitrate lyase, MICA, Threo-D(S)-isocitrate glyoxylate-lyase
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2D12936g
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BRY4

Entry ID Method Resolution Chain Position Source
AF-Q6BRY4-F1 Predicted AlphaFoldDB

No variants for Q6BRY4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BRY4

No associated diseases with Q6BRY4

No regional properties for Q6BRY4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6BRY4

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
  • Glyoxysome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.

3 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPYTKIDVNE EEKFFQDQVK EIQQWWKEPR WAKTKRIYQA EDIAKKRSSL KVDYPSSNQA
70 80 90 100 110 120
KKLYKLLQEH DKNKSASFTF GALDPVQVTQ MAKYLDSIYV SGWQCSSTAS TSNEPSPDLA
130 140 150 160 170 180
DYPMDTVPNK VEHLWFAQLF HDRKQREERL NLSKEERAKT PYTDFLRPII ADADTGHGGI
190 200 210 220 230 240
TAILKLTKLF VERGAAGIHI EDQAPGTKKC GHMAGKVLVP VQEHINRLVA IRASADILGS
250 260 270 280 290 300
DLLCVARTDS EAATLLTSTI DHRDHYFVLG ATNPESPDLA ALMAEAESNG IYGDKLASIE
310 320 330 340 350 360
VEWTKKAGLK LFHEAVIDEI NNGNFSNKQA LIKKFTDKVN PLSATSNKEA RKLAREILGK
370 380 390 400 410 420
DVFFDWDVAR AREGYYRYQG GTQCAVMRGQ AYAPYADMIW MESALPDFKQ AKEFAEGVKA
430 440 450 460 470 480
KWPDQWLAYN LSPSFNWNRA MPPNEQETYI KRLSELGYVW QFITLAGLHT TALAVDDFAN
490 500 510 520 530 540
QYSQIGMRAY GQTIQAPEIE KGVEVVKHQK WSGAEYIDGL LKMVTGGVSS TAAMGAGVTE
DQFKEKAAGK