Q6BRG6

PR
Gene name
ERB1
Protein name
Ribosome biogenesis protein ERB1
Names
Eukaryotic ribosome biogenesis protein 1
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2D16522g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-455 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BRG6

Entry ID Method Resolution Chain Position Source
AF-Q6BRG6-F1 Predicted AlphaFoldDB

No variants for Q6BRG6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BRG6

No associated diseases with Q6BRG6

8 regional properties for Q6BRG6

Type Name Position InterPro Accession
repeat WD40 repeat 429 - 477 IPR001680-1
repeat WD40 repeat 587 - 628 IPR001680-2
repeat WD40 repeat 631 - 669 IPR001680-3
repeat WD40 repeat 672 - 711 IPR001680-4
repeat WD40 repeat 715 - 755 IPR001680-5
repeat WD40 repeat 767 - 811 IPR001680-6
domain BOP1, N-terminal domain 170 - 429 IPR012953
conserved_site WD40 repeat, conserved site 455 - 469 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name Definition
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

2 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARNSKATDT PKTVVEKQSR KRKQDVEDAE ESSSDEELQV EGILDDAASE DEESDSEDAD
70 80 90 100 110 120
KEDDEEEELE GDSDEEFNEL LGEEEDLSDV DSEEFSDEPR DETASITDKL SGTKIRSYSN
130 140 150 160 170 180
ATEDEENEVH TKFSDGRPRI IKPEINPIYD SDDSDNENFN TIGNIPLSAY EEMPHIGYDI
190 200 210 220 230 240
NGKRIMRPAK GSALDQLLES IDLPEGWTGL FDQNTGTSLK ITDDELELIR KIQAQESTDE
250 260 270 280 290 300
NINPYEPTIE WFTSKTEVMP LTAVPEPKRR FVPSKHEAKK VMKIVRAIRE GRIVPPNKVK
310 320 330 340 350 360
EQQEEEKYNF DLWNDNESET KDHIMNLRAP KLPPPTNEES YNPPEEYLMD EEEKKKWLEM
370 380 390 400 410 420
EPEDRDKNYI PQKYNSLRKV PGYQEGLRER FERCLDLYLA PRTRHNKLNI DPDSLIPELP
430 440 450 460 470 480
SPKDLRPFPI RCSTIFQGHT EKIRTLSISP DGLWLATGSD DGSVRIWEIL TGRQVYKTVL
490 500 510 520 530 540
VADDNTDDNI ESLEWNPDSN SGILAAIAGE HIYLIVPPIF GFDIENNGRL RIESGWGYDT
550 560 570 580 590 600
FGNKSKTKNS NIKVNSDDED EEVEKADTNT GKKDVCKWFT PNTEQSQAGI SAIIQCRKTV
610 620 630 640 650 660
KKISWHRKGD YFVTVSPDSG HSSVLIHQLS KHLSQSPFKK SKGIIMDAKF HPFKPQLFVA
670 680 690 700 710 720
SQRYIRIYDL AQQVLVKKLM PGARWLSNID IHPRGDNLLA SSYDKRVLWH DLDLSSTPYK
730 740 750 760 770 780
TLRYHDKAVR SIKFHKANLP LFASASDDGS IHVFHGTVYD DLMTNPLLVP LKKLTGHKII
790 800 810
NSLGVLDLVW HPKEAWLFSA GADGTARLWT T