Q6BRD5

PR
Gene name
POX1 (DEHA2D17248g)
Protein name
Acyl-coenzyme A oxidase
Names
Acyl-CoA oxidase
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2D17248g
EC number
1.3.3.6: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

647-706 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BRD5

Entry ID Method Resolution Chain Position Source
AF-Q6BRD5-F1 Predicted AlphaFoldDB

No variants for Q6BRD5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BRD5

No associated diseases with Q6BRD5

4 regional properties for Q6BRD5

Type Name Position InterPro Accession
domain Acyl-CoA oxidase, C-terminal 510 - 684 IPR002655
domain Acyl-CoA oxidase/dehydrogenase, middle domain 154 - 263 IPR006091
domain Acyl-CoA dehydrogenase/oxidase C-terminal 395 - 469 IPR009075
domain Acyl-coenzyme A oxidase, N-terminal 30 - 142 IPR029320

Functions

Description
EC Number 1.3.3.6 With oxygen as acceptor
Subcellular Localization
  • Peroxisome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

1 GO annotations of biological process

Name Definition
fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVSATNTVNS GVPPNPAASI QAERAASKFD PKEMHYFLEG GEERAEKFKQ MMQQMERDPI
70 80 90 100 110 120
LSANFQYYDL TKDQQRELTA LRIDRLTRYI ENESFDDFNK RMSLMGVFDP QLSTRLGINL
130 140 150 160 170 180
GLFVSCLKGN GTAEQVKYWA MDKSAVYMRG IYGCFGMTEL AHGSNVAGLE TTATFDDEND
190 200 210 220 230 240
EFIINTPHIG ATKWWIGGAA HSATHCSVYA RLIVGGQDYG VKTFVVPLRD SNHDTMPGVT
250 260 270 280 290 300
VGDIGAKMGR DGIDNGWIQF SNVRIPRYFM LQKFCKVSSE GDVQLPPLEQ LSYSALLGGR
310 320 330 340 350 360
VMMVLDSFRV SARFSTVALR YAIGRRQFKA GSASDDKNAL ECQLLDYPLH QRRLLPYLAL
370 380 390 400 410 420
SYIISASAVK IETTIESTLE NLDKAVEADD MGAIMKSIDS MKSLFVDSGS LKSTCTWLAA
430 440 450 460 470 480
EVIDQCRQAC GGHGYSAYSG FGKAYNDWVV MCTWEGDNNV LAMSVGKQII KHILGVLDGK
490 500 510 520 530 540
KVKGSADFLN NTEQYLNEEP VLRSVDDLKD LKKVLLAIEV AIIRVAYQAS QTLKENKGDF
550 560 570 580 590 600
DTVGAEMVTL SKLNAHHFML SEFLDRMDSF ESKQLVPYLE SVAKLYSATI VLEKFAGDFL
610 620 630 640 650 660
AQGVFPPKLN GELNSKHIPE LCKEIRPNVI ALTDSFQQSD MMINSAIGSY DGNIYENYFG
670 680 690 700
VVKANNPPSK TKAPYSGALE AMLNRPSKEE RERFEKSTET AKILSK