Q6BPU5

PR
Gene name
DPH1 (DEHA2E10758g)
Protein name
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Names
Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2E10758g
EC number
2.5.1.108: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BPU5

Entry ID Method Resolution Chain Position Source
AF-Q6BPU5-F1 Predicted AlphaFoldDB

No variants for Q6BPU5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BPU5

No associated diseases with Q6BPU5

No regional properties for Q6BPU5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6BPU5

Functions

Description
EC Number 2.5.1.108 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
2-(3-amino-3-carboxypropyl)histidine synthase activity Catalysis of the reaction S-adenosyl-L-methionine + L-histidine- = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.

1 GO annotations of biological process

Name Definition
peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEPKPEELEK KKVVRRKFIG KRSSVKGDEA SLVKSANKTR HVGRVMNQIP QEILNDKDLN
70 80 90 100 110 120
EAIRLLPSNY NFEIHKTVWN IKKNGAKRVA LQMPEGLLIY SLIISDILEQ FCEVETVVMG
130 140 150 160 170 180
DVSYGACCID DYTARALDCD FIVHYAHSCL VPIDITDIKV LYVFVTINID EQHLINTIKL
190 200 210 220 230 240
NFDKGSQLAV FGTIQFNPTI HSIKSKLEND EEKTMYLIPP QTMPLSKGEV LGCTSARLNK
250 260 270 280 290 300
EQIKAMIYIG DGRFHLESSM IHNPEIPAYR YDPYSRKFTK EYYDQKQMIE VREDAVKIAS
310 320 330 340 350 360
NAKKIGLILG ALGRQGNPVT LNNLETKLSA KGIQVVKIIL SEIFPQKLSM FNDIDAFIQV
370 380 390 400 410
ACPRLSIDWG YAFNKPLLTP YEAMVMLEND TKWNETYYPM DYYSKEGYGR GKVPDHSNVI