Q6BNC5
Gene name |
KAE1 |
Protein name |
tRNA N6-adenosine threonylcarbamoyltransferase |
Names |
N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, tRNA threonylcarbamoyladenosine biosynthesis protein KAE1 |
Species |
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
KEGG Pathway |
dha:DEHA2E22902g |
EC number |
2.3.1.234: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6BNC5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6BNC5-F1 | Predicted | AlphaFoldDB |
No variants for Q6BNC5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6BNC5 | |||||
No associated diseases with Q6BNC5
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.234 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| EKC/KEOPS complex | A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| N(6)-L-threonylcarbamoyladenine synthase activity | Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA threonylcarbamoyladenosine modification | The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVDLDQYAK | PGKDYYLALG | LEGSANKLGV | GVIKHNLGQL | SLDNRAEILS | NVRDTYVTPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEGFLPRDTA | RHHRNWAVRI | IKKALIEAKV | KGSDLDCICF | TQGPGMGAPL | QSVVIAARTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SQLWDLPLVG | VNHCVGHIEM | GREITGADNP | VVLYVSGGNT | QVIAYSRQRY | RIFGETLDIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IGNCLDRFAR | TLRIPNEPAP | GYNIEQMAKK | GKHLVPLPYT | VKGMDLSMSG | ILAHVDSLAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLFAENKNKK | LIDDETGEQI | TSEDLCFSLQ | ETLFSMLVEI | TERAMAHVQS | NQVLIVGGVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNERLQQMME | LMVNDRKNGS | IFATDERFCI | DNGIMIAHAG | LLGYRMGQTN | ELWNTVCTQR |
| 370 | |||||
| FRTDEVFVKW | RDD |