Q6BMV4

PR
Gene name
SRP68 (DEHA2F02354g)
Protein name
Signal recognition particle subunit SRP68
Names
Signal recognition particle 68 kDa protein homolog
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2F02354g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BMV4

Entry ID Method Resolution Chain Position Source
AF-Q6BMV4-F1 Predicted AlphaFoldDB

No variants for Q6BMV4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BMV4

No associated diseases with Q6BMV4

1 regional properties for Q6BMV4

Type Name Position InterPro Accession
domain Signal recognition particle subunit SRP68, RNA-binding domain 9 - 202 IPR034652

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

3 GO annotations of molecular function

Name Definition
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
endoplasmic reticulum signal peptide binding Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.
signal recognition particle binding Binding to a signal recognition particle.

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAYLSSSED YHKQRKRLNK RLLKLRHELD LITPDTKDYK KKEKISKISS SDYDQDEKYG
70 80 90 100 110 120
LLLLLTAERD SLYSSEIKSL LEISNDNASS YRNLMISRIK KSLSSSKKLL EITVNEKDEY
130 140 150 160 170 180
KRIEYYTYAA LIQGNLSVNK KQWSKALNAF SIAKCALDFL YSQEDSKMDI EEEQEESTQF
190 200 210 220 230 240
KKTLISEITE TLVDPSLALA ISQDDTAYST TTDLKTVSRQ HCRDNKLSYL QPVIEIIARI
250 260 270 280 290 300
DPEAVSEVSS STELIKSVQW RDHEATLYND ELAYKIMKLT NDNETNWKNF NDANQFDVLL
310 320 330 340 350 360
SGWSELLEIH TNDMDKNKDE DDLEKVQDRA IVLTYINFNL LFTRLKRDLL IIDQLSSQGD
370 380 390 400 410 420
NVFALKKLEF NKDIIRLYGT IITTTQEIKD LPGVYNDEDL HESLDNLEKF FVAKKSAVLA
430 440 450 460 470 480
RSFALNNKFP EALKIFDHVD NTLSSSDNKF YKIDEFPYNV SSNVEFEKFK KELPSQVLQA
490 500 510 520 530 540
QILAQFSVDL SKNLNQSNFV IENMNKYPVS NETLDNIANF NKNLSIAPVL SKPVLFDIGF
550 560 570 580
NYINYGMGRS SSYNNSNSAT STTSDSTTDQ NDPNKKKSGF FGIFGRS