Q6BKL7

PR
Gene name
SET1 (DEHA2F20834g)
Protein name
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Names
COMPASS component SET1, SET domain-containing protein 1
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2F20834g
EC number
2.1.1.354: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BKL7

Entry ID Method Resolution Chain Position Source
AF-Q6BKL7-F1 Predicted AlphaFoldDB

No variants for Q6BKL7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BKL7

No associated diseases with Q6BKL7

4 regional properties for Q6BKL7

Type Name Position InterPro Accession
domain SET domain 946 - 1069 IPR001214
domain Post-SET domain 1072 - 1088 IPR003616
domain Histone lysine methyltransferase SET associated 438 - 503 IPR024636
domain COMPASS complex Set1 subunit, N-SET domain 773 - 940 IPR024657

Functions

Description
EC Number 2.1.1.354 Methyltransferases
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

2 GO annotations of molecular function

Name Definition
histone methyltransferase activity (H3-K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
nucleic acid binding Binding to a nucleic acid.

2 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYNPYRSRN YGGGYSNNGY RQRHYYSDYN ESSYNSSYRD QYDRNGSYSG SKGRHYNSGT
70 80 90 100 110 120
SRNAPPPSSS AYSSDSSSRT YANSSSSGPA KIPVGPKSLT IDGSTNGDLP TAGTQKHNIP
130 140 150 160 170 180
PTNAISGTDA TTGVNPNDSN FTQLLLHQDL SKQIEFSGEI DSKRNYKVIY DPELDKSLSK
190 200 210 220 230 240
AERKTKQKKI RFNGESLSSH DVTDPRKSST GSTSAYFLKP NKKSKKFPFK QLPQPKFIYD
250 260 270 280 290 300
KDSLGPPPQN EIVVWDLPST TSEVYLSNFF KSYGDSIKDL KFINDPLNAV PLGIATCKFQ
310 320 330 340 350 360
GNPDKSMRIA KKFIANVRIN HTKIDGAELK IALNDNDNKL LDDKIKVAQD KLRISRIKIE
370 380 390 400 410 420
EEEKKRLKKQ QAIEDQKRRE TEKAAKEKKL QESANSSHES RFKPNTTTLS IRHHNEVIPG
430 440 450 460 470 480
VFLPRELRKY IRDRPYIFIN DKYVPTRKVS SQDIKKVLNK YDWTRVLPDR SGFFVVFNSI
490 500 510 520 530 540
KECERCFINE DGRKFFEYKM FMELALPENF NESSSSTSNN DNTDLSASNR KQNDVVEEAS
550 560 570 580 590 600
NMLIKEFQNF LAKDIRERVI APVVLDLLSH DKYPKLVEEL KAKELATKKA ASPIVTNAVR
610 620 630 640 650 660
QVKSKPNVLS SLAIKSKPQA ILPSFRKKKD LPNAGLNSAN KAKKNVIPMQ HALNYDHESD
670 680 690 700 710 720
ESDEDDSTRS TTPLTPTLKR ERSPTVSSVS NDNDIEDKLE DIQKPSKKKQ KKTKLHQSFL
730 740 750 760 770 780
YDSASDEDME AVSEEKEVEK DESEGEEDID YSHIDKIYQP TEDYPRPVYE EVPRFPSDPL
790 800 810 820 830 840
DLDALQSIIK DDEDITLLQT ALADVTSESN IKNMEYWAWK QKDIKAKAGV QEISEDLEVI
850 860 870 880 890 900
GPLDSRFDSK SGAFKSEGYR KIPDADKIEY LPHRRKIHKP IKTIQHDDDE LNANNSTTNN
910 920 930 940 950 960
NSNNIQSSRV NRANNRRFAA DISAQKQMLG SETDILNLNA LTKRKKPVSF ARSAIHNWGL
970 980 990 1000 1010 1020
YALEPIAAKE MIIEYVGESI RQQVAEHRER SYLKTGIGSS YLFRIDENTV VDATKKGGIA
1030 1040 1050 1060 1070 1080
RFINHCCNPS CTAKIIKVEG KKRIVIYALR DIEANEELTY DYKFEKETND AERIRCLCGA
PGCKGYLN