Q6BIP2
Gene name |
RAD5 (DEHA2G08800g) |
Protein name |
DNA repair protein RAD5 |
Names |
|
Species |
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
KEGG Pathway |
dha:DEHA2G08800g |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6BIP2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6BIP2-F1 | Predicted | AlphaFoldDB |
No variants for Q6BIP2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6BIP2 | |||||
No associated diseases with Q6BIP2
6 regional properties for Q6BIP2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SNF2, N-terminal | 435 - 845 | IPR000330 |
| domain | Helicase, C-terminal | 1014 - 1181 | IPR001650 |
| domain | Zinc finger, RING-type | 916 - 963 | IPR001841 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 428 - 746 | IPR014001 |
| domain | HIRAN domain | 177 - 292 | IPR014905 |
| conserved_site | Zinc finger, RING-type, conserved site | 934 - 943 | IPR017907 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTMEKKRYFS | VMSEDRSPNL | VTAEQNEELK | NSSVSKDSQE | DSLFVVDDSD | IEEQTESNIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENTNPVPHVH | RLEYEEFESQ | IKSVVGTISS | HAMNHLFKKY | HDKQNYLKLA | VQEYLQGIDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NDTDIRIVGN | SPDGNNSPNV | HRKRIYEQEQ | DDLMSRLQRE | CQRSQDEEKK | KSWNRFIGSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVQAWATRPT | TKPLKYLEKL | ELRRLMPKKL | NVGKPTKEKT | KFGDSSIIRI | YTIPKYTEES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GREIGRIPED | ITRILVPLID | LDISSFYTTV | MIDTEKRLST | GDSFYIQIDC | YLSQNAFSGK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELERSMSQSD | QDLNALKRQK | KMDTRTRFDF | STETNTEAIL | RLRQYSLSRF | FQRLNIKPIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QKSDHADDIN | EASETPIIID | SENEDDHIVK | EDHEQQNLDQ | LKQIMQANQQ | SELLDSLPET |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TKPPIFNFKL | DLRKYQKHGL | SWMLTREREI | AVLETLSKND | DDDNDNDILT | TQDKANIQER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NDAFMNPLWD | IFEWPKDTSM | HKSESSPTED | RMDDNYFYAN | MYNGELSLTK | PVIRSMVKGG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILADEMGLGK | TISTLALINS | VPIDVMFEEN | KELEDKTIYA | SKTTLIIVPM | SLLSQWQKEF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DKANNNSNHK | CFIYYGDSAT | TDLSPVLCNK | KKDIPIVMIT | TYGTVLNEFT | RISNRRDAKG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FLPKIGLFSV | KFFRIVLDEG | HNIRNRTAKT | SKAIYEILSN | RKWVLTGTPV | INRLDDLYSL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VKFLELEPWS | NFSYWKTFVT | LPFEQRKISQ | TLDVVKSILE | PIFIRRTKNM | KQSNGKPLVE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LPPKEVVIEE | VKFNEVEEKL | YNWFKARASQ | SFKDGIKSGD | LFKKYSQILT | HILRLRQVCC |
| 850 | 860 | 870 | 880 | 890 | 900 |
| HVDLVGSANE | MEQELVDPNT | DLSEANGESD | SISMVNNVLD | SYHADNNHDE | KFKNNTEVRS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VMFPLYEKID | LKESECSICT | QSPIPLGEMA | LTPCGHAYCL | NCVLEHFDFQ | EKNSQKPLCP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NCREPISKYK | IFKLRHRDTS | VKEIRFHTKQ | EMEDPSQNFK | FQLYLYDPTK | TSSKIQCLIN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| HLKILKEQSP | NEQVVVFSQF | SSYLDIIENE | LKIQISNDFV | VYKFDGRLNM | NERQKILENF |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SSQKHENKVM | ILLLSLKAGG | VGLNLTTASR | AFMMDPWWSP | SVEDQAIDRL | HRIGQNSNVK |
| 1150 | 1160 | 1170 | 1180 | ||
| VTRFIMADSI | ETKMLKIQER | KKQIGEAVGA | EEDERRKRRI | EEMQILFEDD |