Q6BH05

PR
Gene name
NUT1 (MED5, DEHA2G22352g)
Protein name
Mediator of RNA polymerase II transcription subunit 5
Names
Mediator complex subunit 5
Species
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KEGG Pathway
dha:DEHA2G22352g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6BH05

Entry ID Method Resolution Chain Position Source
AF-Q6BH05-F1 Predicted AlphaFoldDB

No variants for Q6BH05

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6BH05

No associated diseases with Q6BH05

No regional properties for Q6BH05

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6BH05

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASSTATVSL HNLVKLCCKR NSTSKVFVSL YNQLEEKSPI QDNDYLSNLL QPDIKNKSKR
70 80 90 100 110 120
ESSLITEYIL ALAISSESQL EKFWKFLPEI LLENQIHYMI ELNSILLSKS NIERPSSDIF
130 140 150 160 170 180
KEIVNNCFFK YTSSYISSLF PGISATQVSL LNHIIVVWCS VIRRSPFHLN TSSFKQLAVK
190 200 210 220 230 240
IVSVLTECDL RNSLNYFISN TSSILNTDDL QVDSVQDSDD KKIAAIRSTT TIQLVNNISS
250 260 270 280 290 300
INPKSRKATQ LNVIKRYLWL NSIMKNWKFS NDVFLKQFEQ NFLPNSSNNL KKPYVLAFEL
310 320 330 340 350 360
ICAFFKGIVT SICSNESKYV LFNWKNFIIT RLPTLLNDIK FTTSHVAPTS NDSSFKQETL
370 380 390 400 410 420
DDAIINAFES FEDPVNKVLT QFSIDNLSIC DLRQTFIKSC IYNKLIPVMS YHKIFTADNT
430 440 450 460 470 480
VTDQFLNNGI EQVGQITSIR DEFETKLLNI NTEFTTLEDS GLIEYINSLP GLLEFSATKQ
490 500 510 520 530 540
LELSETVDQV IEHLIDEKNI EKLYRLLLSV CNNLTTLNLI CFNSNCGPFS ILYKLINYID
550 560 570 580 590 600
NEDFNVDDDD NFQETYAFFG IIILAILLII ETFKIDYSQI TVTNSYIVDY INEFYYRLCD
610 620 630 640 650 660
SLTNISTSDT EEDNTIISNY NDLISDWINA LFDDNNDGLS DDLIKSVNVK QIYKMIPIIY
670 680 690 700 710 720
QQSIIATNSN KIDIKILNNG IDYLSQMFLI PCTLNIIKWL LRRIWADDPT LDCLPVQVLH
730 740 750 760 770 780
ELIKSNMGES DEPTSESKLF FQIVLKISGN SIISTLKKLN NWENSNLIKD IIEKVSNSVD
790 800 810 820 830 840
PMYLENDLSI KLNERVNLYE QLKTNVINLV NNMNIYDYQF LNIFSSIDRD NELIRYIVEE
850 860 870 880 890 900
ITSYQKTNGG NEDTKLFINL SIFMILLDAI DNDDDKQYWI KRIKDTMVPV SSNSSGENRF
910 920 930 940 950 960
DISMDYHYSS IFNNSDETSN NDYLFSGENN NSSVEIEGLK RKIGRHESLL NSFNKIKEFC
970 980
DTEVQSTFVK SLRTFRDKLI NELEVFTLNV