Q6AYK5

PR
Gene name
Lyar
Protein name
Cell growth-regulating nucleolar protein
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:289707
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AYK5

Entry ID Method Resolution Chain Position Source
AF-Q6AYK5-F1 Predicted AlphaFoldDB

No variants for Q6AYK5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AYK5

No associated diseases with Q6AYK5

2 regional properties for Q6AYK5

Type Name Position InterPro Accession
domain Zinc finger, C2H2, LYAR-type 31 - 58 IPR014898
domain Acetyl-coA carboxylase zinc finger domain 3 - 28 IPR041010

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Cytoplasm
  • Cell projection, cilium, photoreceptor outer segment
  • Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (By similarity)
  • Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247)
  • In the retina, predominantly expressed in photoreceptor outer segments
  • In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

5 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
identical protein binding Binding to an identical protein or proteins.
metal ion binding Binding to a metal ion.
transcription regulator inhibitor activity A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.

7 GO annotations of biological process

Name Definition
erythrocyte development The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of innate immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis.
positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NX58 LYAR Cell growth-regulating nucleolar protein Homo sapiens (Human) PR
10 20 30 40 50 60
MVFFTCNACG ESVKKIQVEK HVSICRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG
70 80 90 100 110 120
KGYEAKTHKG DVKQQAWIQK INELIKKPNV SPKVRELLQQ ISAFDNVPRK KAKFQNWMRN
130 140 150 160 170 180
SLKVHSDSVL EQVWNIFSEA ASSEQDQQPP SHMAKPNTEV PTKVPSTKTN GTTEEQTEAK
190 200 210 220 230 240
KNKRERKEER QKSRKKEKKE LKLENHQENL KGQKPKKRKK GQEAGHEAGG EDAAEANGAP
250 260 270 280 290 300
EKKRARDAQA SEEGADRNGG PAEDADEGPT KTAAGKRKRQ KHSEVESDNK KKKMKLPGQP
310 320 330 340 350 360
EEGEPEDHEA PSKGKFNWKG TIKAVLKQAP DNEISVKKLK KKVIAQYHAV MSDHHTSEEE
370 380
LLAIFNKKIS RNPTFKVLKD KVKLLK