Q6AYJ5

PR
Gene name
Cluap1
Protein name
Clusterin-associated protein 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:363544
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

238-402 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AYJ5

Entry ID Method Resolution Chain Position Source
AF-Q6AYJ5-F1 Predicted AlphaFoldDB

1 variants for Q6AYJ5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs8163070 362 N>D No EVA

No associated diseases with Q6AYJ5

No regional properties for Q6AYJ5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6AYJ5

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary base Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
ciliary tip Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
intraciliary transport particle A The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.
intraciliary transport particle B The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
axoneme assembly The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
floor plate formation The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.
heart looping The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
left/right pattern formation The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
neural tube closure The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8R3P7 Cluap1 Clusterin-associated protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MMRALGYPRH ISMENFRTPN FGLVSEVLLW LVKRYEPQTD IPSDTETEQD RVFFIKAIAQ
70 80 90 100 110 120
FMATKAHIKL NTKKLYQADG YAVKELLKIT SVLYNAMKTK GMEGSNVGEE DISKFKFDLG
130 140 150 160 170 180
SKIADLKAAR QLASEITAKG ASLYDLLGKE VELRELRTEA IARPLEINET EKVMRIAIKD
190 200 210 220 230 240
ILAQVQKTKD LLNNVASDEA NLEAKIEKRK LELERNRKRL QTLQSVRPAF MDEYEKVEEE
250 260 270 280 290 300
LQKQYDVYLE KFRNLAYLEQ QLEDHHRMEQ ERFEEAENTL RLMQNKLKEE EKRLLKSGSN
310 320 330 340 350 360
DDSDIDIQED DESDSELEDR RLSKPRTAME VLMQGRPSKR IVGTMQGGDS DEDEDSEDSE
370 380 390 400
MNMEDDEEDD DDLEDESIAL SPAKPSRRVR KPEPLDESDN DF