Q6AY01

PR
Gene name
Rnf133
Protein name
E3 ubiquitin-protein ligase RNF133
Names
RING finger protein 133, RING-type E3 ubiquitin transferase RNF133
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:681395
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

282-381 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AY01

Entry ID Method Resolution Chain Position Source
AF-Q6AY01-F1 Predicted AlphaFoldDB

No variants for Q6AY01

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AY01

No associated diseases with Q6AY01

2 regional properties for Q6AY01

Type Name Position InterPro Accession
domain Zinc finger, RING-type 254 - 297 IPR001841
domain PA domain 72 - 162 IPR003137

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.

2 GO annotations of biological process

Name Definition
protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPLQTGPWQ TSAPSFWLLK FSFIWLVSQN CCTASAVWTA YMNISFHVGN RMLSELGETG
70 80 90 100 110 120
VFGRSSILKR VAGVVVPPEG KIQNACDPNT SFILPRNKEP WIALIERGGC AFTQKIKVAS
130 140 150 160 170 180
ENGARGVIIY NFPGTGNQVF PMSHQAFEDI VVVMIGNVKG MEILHLIRKG VHVTVMVEVG
190 200 210 220 230 240
RKHVIWLNHY FVSFMIVTTA TLAYFTFYHI RRLWVARIED RRWKRLTREL KKAFGQLQVR
250 260 270 280 290 300
ILKEGDEEVS PNADSCVICF EAYKPNEIVR ILTCKHFFHK NCIDPWILAH GTCPMCKCDI
310 320 330 340 350 360
LKALGIQMDI EDGSDSLQVL MSNELPGTFS AMEEELNNEL PPARTSSKVT HVQEHPTSVN
370 380
VGSQPPEAEE TGHPSFGQHD L