Q6AXQ8
Gene name |
Mns1 |
Protein name |
Meiosis-specific nuclear structural protein 1 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:363093 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6AXQ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6AXQ8-F1 | Predicted | AlphaFoldDB |
1 variants for Q6AXQ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs107539501 | 175 | V>A | No | EVA |
No associated diseases with Q6AXQ8
1 regional properties for Q6AXQ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Trichohyalin-plectin-homology domain | 115 - 465 | IPR043597 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| axonemal microtubule | A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. |
| axoneme | The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
| intermediate filament | A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. |
| motile cilium | A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| sperm flagellum | A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| left/right axis specification | The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| positive regulation of cilium assembly | Any process that activates or increases the frequency, rate or extent of the formation of a cilium. |
| sperm axoneme assembly | The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANKKRAMSF | SEKHQQLVDE | NFRKSLHVQV | LNKLERQAKN | QVVQNENDER | VERQRFLRVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QNEQFELDME | EAVQKAEENK | RMRDRQLEQE | ERLANELARL | KHESLKDEKM | RQQVRENSIE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRELEQKLKA | AYMNKERAAQ | IVEKDVIKYE | QMKRDAEIER | IMMEEHKRLL | KEENVKQEKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DKERAQYYVD | LEKQLEDQER | RKQEAYEQLL | KEKLMIDEIV | RKIYEEDQLE | RQQKLEKRNA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IQKYIKEFQR | AQDLWRQKKR | EEMEEENRKI | LEFAKIQEQR | EGERMARVQE | SEEKRVQRQN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLIQKLEETL | RQRDDLERVR | QELYLEEYAE | FIKLKMKEEV | EQRLRKQRDR | KQDFKDQMAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| REVLLQAAKE | EEEAFKKAML | AKFAEDDRIE | LMNAQKQRMK | QLEHKRAVEK | LIEERRNQFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ADKQRELEEL | QLQQRRQGCI | NEIIEEERLR | LLKEHASKLL | GYLPKGVFKK | EDDVDMLGEE |
| 490 | |||||
| FRKAYQKKSE | VCEEKGSS |