Q6AX60

PR
Gene name
bbs9 (pthb1)
Protein name
Protein PTHB1
Names
Bardet-Biedl syndrome 9 protein homolog, Parathyroid hormone-responsive B1 gene protein homolog
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:447236
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

181-259 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AX60

Entry ID Method Resolution Chain Position Source
AF-Q6AX60-F1 Predicted AlphaFoldDB

No variants for Q6AX60

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AX60

No associated diseases with Q6AX60

2 regional properties for Q6AX60

Type Name Position InterPro Accession
domain PTHB1, N-terminal domain 1 - 417 IPR028073
domain PTHB1, C-terminal domain 442 - 819 IPR028074

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium membrane
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
BBSome A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B.
ciliary membrane The portion of the plasma membrane surrounding a cilium.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLFKARDWW SASLGEKEEF DQGCLCVADV DNSGTAHDKI IVGSFSGYLR IFSPHPLKPG
70 80 90 100 110 120
DGMQAEDLLL EVQLRDPVLQ VEVGKFVSGT EILHLAVLHP RKLCVYSVSG TLGNVEHGNQ
130 140 150 160 170 180
YQMKLMYEHN LQRTACSMTH GPFGGVKGRD LICIQSMDGM LMFFEQESYA FGRYLPGFLL
190 200 210 220 230 240
PGPLSYSPKT DSFVTVSSSR QVESYKYQVL AVATDADSRK ENEQQKMGAG KKVVADWILN
250 260 270 280 290 300
IGEQALDISI VSFNQTSFSI FVLGERNFFC LKESGQIRFM KKLDYSPSCF HPYSSVNDGT
310 320 330 340 350 360
INTLVGNHNN MLLVYQDVTL KWAAQLSQTP VAVKVANFRD LKGVIVTLSE SGQLQCSYLG
370 380 390 400 410 420
TDPSLFQVPK VESRDINYED LDVEMKELQR IIKEATKTQD ILPKMEKDDD LTLVATVLPD
430 440 450 460 470 480
LDSVSQAVDG EVESEVIPSV SVKLCVRSRL TLQKAVLLIS TPAPLALTQD QFIFDSLEPG
490 500 510 520 530 540
VSKTASASVF LKGNYPPADL EGSAVVSYSK PTELNPEGVP RIVQCKFRLP LKLVCFPVQP
550 560 570 580 590 600
SKVANHKLTI DTNKPPVNLI NLFPEFIDQV EEDQVSVVGF QLLAGQKVTL LASKTSQRYR
610 620 630 640 650 660
IQSEQFEDLW LITREFILRF QDYFLKQGIK DFTCSFSGPV PLQEYFELID QHFELRLNGE
670 680 690 700 710 720
KYEALLSERA VQFRAIQRLL LTRFKDKTPT PLQNLDTLLD GTYRQVIGIA DAAEELQRNL
730 740 750 760 770 780
FRAFTRLKSA TQLVILLIGL WQKLNKEQIA ILEGTFLPLL KDGQELGWEE SVDAALSHLL
790 800 810 820 830 840
RTCLSKSSKE QALNLTSHLS IPKDTSRLKK HITLLCERMS KGGRLSLSAD SGSQQAAEMQ
GTPINPSVS