Q6AK95

PR
Gene name
purC
Protein name
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Names
SAICAR synthetase
Species
Desulfotalea psychrophila (strain LSv54 / DSM 12343)
KEGG Pathway
dps:DP2502
EC number
6.3.2.6: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

119-204 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AK95

Entry ID Method Resolution Chain Position Source
AF-Q6AK95-F1 Predicted AlphaFoldDB

No variants for Q6AK95

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AK95

No associated diseases with Q6AK95

2 regional properties for Q6AK95

Type Name Position InterPro Accession
conserved_site SAICAR synthetase, conserved site 109 - 123 IPR018236
domain SAICAR synthetase/ADE2, N-terminal 13 - 295 IPR028923

Functions

Description
EC Number 6.3.2.6 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEAMLTTDF PQLNLVHSGK VRDMYAIPGH DDKLLMVATD RISAYDVILS AIPGKGAILT
70 80 90 100 110 120
QLSLFWFDLL ADIVDNHMIT ADVTEYPEAC APYAEQLRGR SILVKRTKPL PIECIVRGYI
130 140 150 160 170 180
SGSFWKAYQQ DTNVCGFQLP EGMQESDKFP EPIFTPSTKA ELGDHDENIS FERMQEIVGV
190 200 210 220 230 240
EKAEQIARIS KALYTRAADY ARTKGVIIAD TKFELGEVDG KIILIDEVLT PDSSRFWAAD
250 260 270 280 290
KYEPGKSQES FDKQYLRDYL SSLDWDKNPP APPLPEEIIV KTKARYDEAV ERITGK