Q6AFZ0

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Leifsonia xyli subsp xyli (strain CTCB07)
KEGG Pathway
lxx:Lxx07970
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AFZ0

Entry ID Method Resolution Chain Position Source
AF-Q6AFZ0-F1 Predicted AlphaFoldDB

No variants for Q6AFZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AFZ0

No associated diseases with Q6AFZ0

4 regional properties for Q6AFZ0

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 84 - 95 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 54 - 710 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 761 - 904 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 716 - 891 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVPRRSRQRP ASSCRTAKTA RREMPYPLPA PDGQEPEAQP VTPSPVFPEI EEDVLAFWDR
70 80 90 100 110 120
DGTFHASIDN RDGAPEWVFY DGPPFANGLP HYGHLMTGYA KDVFPRYQTM RGKKVERRFG
130 140 150 160 170 180
WDTHGLPAEL EAERQLGITD KSQIEEMGLA AFNQAAKDSV LKYTREWQQY VTRQARWVDF
190 200 210 220 230 240
DNGYKTLDTT YMESVIWAFK QLHEKGLAYE GYRVLPYCWR DQTPLSNHEL RMDDDVYKMR
250 260 270 280 290 300
QDQTVTVTFP LTGAKAESLG LTGVRVLAWT TTPWTLPTNL ALVVGPDIQY AVVPAGPNGA
310 320 330 340 350 360
ADAHGRPDDE VLSGEYLLAI DLVGNYAKDL GYGSPEAARA AVTRTIPGRE LEGVTYDRLW
370 380 390 400 410 420
DYYADAATWG TQNAWQILVD GYVTTEDGTG IVHQAPAYGE DDQRVCEAAG IPVIISVDDG
430 440 450 460 470 480
ARFLPAVQDV AGLQVFEAGK PLIKLLREEG RLLRQASYEH SYPHCWRCRN PLIYKAVSSW
490 500 510 520 530 540
FVRVTDFRDR MVALNQEITW VPENVKDGQF GKWLAGARDW SISRNRYFGS PIPVWKSDDP
550 560 570 580 590 600
DYPRVDVYGS LAELERDFGR LPLNAAGEPD LHRPFVDDLT RPNPDDPTGR STMRRIPDVL
610 620 630 640 650 660
DVWFDSGSMP FAQVHYPFEN SDWFDSHNPA DFIVEYIGQA RGWFYLLHAL STALFDRPAF
670 680 690 700 710 720
TNVISHGIVL GNDGQKVSKS LRNYPDVNDV FDRDGSDAMR WFLMSSPVLR GGNLVVTEEG
730 740 750 760 770 780
VREGVRQVLL PLWNTWYFFS LYANATGYEA KRSTASAAVL DRYLLAKTRD LVEAVTADLD
790 800 810 820 830 840
ALDSTLASAK LRDFADLLTN WYVRRSRDRF WAGVDGEGAG AEAFDTLYTV LETLTRVAAP
850 860 870 880 890 900
LLPLVTERIW KDLTGGRSVH LTDWPDAAEL PADDALVAAM DRVRAISSTA LSLRKQAGLR
910 920 930 940 950 960
VRLPLASLTV VAEGAAALAP FEAILRDELN VKAVCLVEGE HSGVDRALTV KARQLGPRIG
970 980 990 1000 1010 1020
KRVQEVIRAA KSGDWSEADG VVTAGGVELE PGEYELAVVI SAPTARFENG VYIELDTALT
1030 1040 1050 1060 1070 1080
PELEAEGLAR DIIRAVQDTR KAAGLGVSDR IALTLAFENG GDARVLGLAT EVDIASETLA
1090 1100 1110
RTVQVAAAAG AFVKTFGAGQ FANVGDFTVG ITKIEEADE