Q6A009
PR
Gene name |
Ltn1 (Kiaa0714, Lister, Rnf160, Zfp294, Znf294) |
Protein name |
E3 ubiquitin-protein ligase listerin |
Names |
RING finger protein 160, RING-type E3 ubiquitin transferase listerin, Zinc finger protein 294, Zfp-294 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78913 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6A009
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6A009-F1 | Predicted | AlphaFoldDB |
102 variants for Q6A009
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389423389 | 48 | V>A | No | EVA | |
| rs3389417705 | 90 | M>L | No | EVA | |
| rs3389339636 | 95 | D>V | No | EVA | |
| rs3389421929 | 96 | T>S | No | EVA | |
| rs3389434619 | 106 | W>C | No | EVA | |
| rs3389423422 | 123 | E>G | No | EVA | |
| rs3389417366 | 137 | K>* | No | EVA | |
| rs3389424363 | 143 | Y>H | No | EVA | |
| rs3389434557 | 144 | L>F | No | EVA | |
| rs3389417397 | 148 | M>V | No | EVA | |
| rs3389339669 | 160 | P>L | No | EVA | |
| rs3389426221 | 190 | I>N | No | EVA | |
| rs3389423348 | 222 | H>P | No | EVA | |
| rs3389434596 | 235 | L>M | No | EVA | |
| rs248025286 | 253 | S>T | No | EVA | |
| rs3412830677 | 275 | Y>* | No | EVA | |
| rs3389384626 | 279 | V>A | No | EVA | |
| rs3389373790 | 299 | P>L | No | EVA | |
| rs3389392987 | 308 | S>N | No | EVA | |
| rs3389440494 | 350 | E>* | No | EVA | |
| rs213289545 | 357 | A>S | No | EVA | |
| rs226414950 | 359 | M>I | No | EVA | |
| rs242690002 | 359 | M>V | No | EVA | |
| rs235868010 | 444 | T>I | No | EVA | |
| rs224941982 | 453 | H>Q | No | EVA | |
| rs3407154992 | 459 | H>R | No | EVA | |
| rs3407288334 | 462 | D>V | No | EVA | |
| rs242743702 | 477 | P>A | No | EVA | |
| rs3389440424 | 496 | E>* | No | EVA | |
| rs242909560 | 503 | R>C | No | EVA | |
| rs3389413873 | 505 | P>T | No | EVA | |
| rs230010280 | 530 | K>N | No | EVA | |
| rs214365982 | 553 | E>K | No | EVA | |
| rs230027898 | 557 | S>C | No | EVA | |
| rs252470137 | 561 | E>D | No | EVA | |
| rs260858858 | 603 | S>N | No | EVA | |
| rs3389440409 | 633 | L>F | No | EVA | |
| rs3389440451 | 637 | K>R | No | EVA | |
| rs3389393038 | 655 | K>N | No | EVA | |
| rs3389413854 | 671 | N>S | No | EVA | |
| rs3389423401 | 704 | D>E | No | EVA | |
| rs3389384566 | 708 | E>D | No | EVA | |
| rs3389440432 | 715 | L>F | No | EVA | |
| rs3389373807 | 717 | Q>H | No | EVA | |
| rs3389392961 | 717 | Q>K | No | EVA | |
| rs3406336282 | 719 | I>L | No | EVA | |
| rs3389384548 | 734 | P>S | No | EVA | |
| rs3389423364 | 785 | Y>* | No | EVA | |
| rs3389421983 | 787 | I>N | No | EVA | |
| rs3389426223 | 802 | T>S | No | EVA | |
| rs255979589 | 831 | S>R | No | EVA | |
| rs244060525 | 837 | L>W | No | EVA | |
| rs223244166 | 839 | M>R | No | EVA | |
| rs3389440425 | 851 | Q>R | No | EVA | |
| rs3389423374 | 880 | L>S | No | EVA | |
| rs3389426174 | 882 | V>A | No | EVA | |
| rs3389373717 | 892 | S>T | No | EVA | |
| rs212064172 | 900 | L>M | No | EVA | |
| rs3389404202 | 900 | L>Q | No | EVA | |
| rs251391585 | 904 | D>N | No | EVA | |
| rs3389413849 | 920 | L>M | No | EVA | |
| rs3389434573 | 922 | A>T | No | EVA | |
| rs3389384621 | 923 | A>G | No | EVA | |
| rs3389430162 | 959 | A>V | No | EVA | |
| rs3389384585 | 987 | E>V | No | EVA | |
| rs4214280 | 1009 | V>I | No | EVA | |
| rs4214279 | 1011 | Q>P | No | EVA | |
| rs260237852 | 1021 | V>I | No | EVA | |
| rs3389426245 | 1023 | E>K | No | EVA | |
| rs3389423409 | 1024 | K>* | No | EVA | |
| rs3389339689 | 1034 | Q>K | No | EVA | |
| rs4214268 | 1042 | A>P | No | EVA | |
| rs240855201 | 1138 | K>R | No | EVA | |
| rs3389339719 | 1183 | Q>H | No | EVA | |
| rs3389430189 | 1259 | T>I | No | EVA | |
| rs218223255 | 1264 | A>V | No | EVA | |
| rs3389373803 | 1302 | V>I | No | EVA | |
| rs254671754 | 1328 | I>V | No | EVA | |
| rs3389440430 | 1345 | K>N | No | EVA | |
| rs3389404207 | 1353 | Y>* | No | EVA | |
| rs3389423442 | 1384 | L>M | No | EVA | |
| rs248000683 | 1445 | S>T | No | EVA | |
| rs3406336277 | 1447 | E>Q | No | EVA | |
| rs3389339686 | 1457 | V>I | No | EVA | |
| rs3389424397 | 1466 | K>T | No | EVA | |
| rs3389413839 | 1469 | S>T | No | EVA | |
| rs3389430197 | 1472 | F>L | No | EVA | |
| rs3389339668 | 1492 | A>V | No | EVA | |
| rs3389434585 | 1496 | L>F | No | EVA | |
| rs3389423430 | 1540 | K>E | No | EVA | |
| rs3389392950 | 1551 | I>N | No | EVA | |
| rs3389430034 | 1562 | P>L | No | EVA | |
| rs3389424335 | 1573 | L>* | No | EVA | |
| rs3389393044 | 1604 | S>C | No | EVA | |
| rs3389423358 | 1635 | E>V | No | EVA | |
| rs3407228140 | 1661 | S>L | No | EVA | |
| rs3407288290 | 1662 | I>L | No | EVA | |
| rs3407086133 | 1662 | I>M | No | EVA | |
| rs3389392960 | 1665 | E>G | No | EVA | |
| rs3389434614 | 1668 | K>R | No | EVA | |
| rs3389426215 | 1682 | L>M | No | EVA | |
| rs3389430195 | 1750 | W>* | No | EVA |
No associated diseases with Q6A009
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| RQC complex | A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribosomal large subunit binding | Binding to a large ribosomal subunit. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein autoubiquitination | The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. |
| rescue of stalled ribosome | A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex. |
| ribosome-associated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VW09 | Ltn1 | E3 ubiquitin-protein ligase listerin | Drosophila melanogaster (Fruit fly) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGGKNKQRTK | GNLRPSNSGR | AAELLAKEQG | TVPGFIGFGT | SHSDLGYVPA | VQGAEDIDSL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDSDFRMVLR | KLSKKDVTTK | LKAMQEFGIM | CTERDTEAVK | GVLPYWPRIF | CKISLDHDRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VREATQQAFE | KLILKVKKHL | APYLKSVMGY | WLMAQCDTYP | PAALAAKDAF | EAAFPPSKQP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAIAFCKEEI | TTVLQDHLLK | ETPDTLSDPQ | TVPEEEREAK | FHRVVTCSLL | ALKRLLCFLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NNELDSLEEK | FKSLLSQNKF | WKYGKHSVPQ | VRSAYFELVS | ALCQHVPQVM | KEEAAKVSPS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLLSIDDSDP | VVCPALWEAV | LYTLTTIEDC | WFHVNAKKSV | FPKLMAMIRE | GGRGLAAVMY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PYLLPFISKL | PQSITEPKLD | FFKNFLTSLV | TGLSTERTKS | SSSECSAVIS | AFFECLRFIM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QQNLGEEEMV | QMLINEQLIP | FIDTVLKDSG | LHHGPMFDHL | ADTLSSWEAK | ADAERDPGAV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YNLENVLLSF | WGRLSEICTE | KIRQPEADVK | SVLCVSSLVG | VLQRPRSSLK | LHRKKTAQVR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FAINIPEAHK | GDEKSMSSEG | ENSEGSDGGA | QSPLSNTSSD | LVSPLRKKPL | EDLVCKLAEV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SISFVNERKS | EQHLQFLSTL | LDSFSSVQVF | NILLSDKQKN | VVKAKPLEIT | KLAEKNPAVK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FLYHKLIGWL | NDSQKEDGGF | LVDILYSALR | CCDSGVERKE | VLDDLTKEDL | KWSSLLQVIE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KACSSSDKHA | LVTPWLKGSI | LGEKLVALAD | CLCDKDLEAT | TSESHSSEQW | SLLRLALSQH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VKNDYLIGEV | YVGRIIVKLH | ETLSKTKDLS | EAANSDSSVS | FVCDVVHSFF | SSAGGGLLMP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PSEDLLLTLF | QLCAQSKERT | HLPDFLICKL | KNTLLSGVNL | LVHQTASTYE | QSTFLRLSVL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WLKDQVQSSA | LDNTSLQVLL | SAAGDLLGTL | VESEDTSLLG | VYIGSVMPSD | SEWEKMRQAL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PVQWLHRPLL | EGRLSLNYEC | FKTDFKEQDT | KTLPNHLCTS | SLLSKMILVA | QKKKLVLEDN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VLEKIIAELL | YSLQWCEELD | NAPSFLSGFC | GILQKMNITY | SNLSVLSETS | SLLQLLFDRS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RKNGTLWSLI | IAKLILSRSI | SSDEVKPYYK | RKESFFPLTE | GSLHTIQSLC | PFLSKEEKKE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FSAQCIPAFL | GWTKEDLCSI | NGAFGHLAIF | NSCLQTRSID | DKQLLHGILK | IITSWRKQHE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| DIFLFSCNLS | EASPEVLGLN | IEIMRFLSLF | LKHCAYPLPL | ADSEWDFIMC | SMLAWLETTS |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ENQALYSVPL | VQLFACVSFD | LACDLCAFFD | SITPDIVDNL | PVNLISEWKE | FFSKGIHSLL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LPLLVNAIGE | NKDLSETSFQ | NAMLKPMCET | LTYISKDQLL | SHKLPARLVA | SQKTNLPEHL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| QTLLNTLTPL | LLFRARPVQI | AAYHMLCKLM | PELPQHDQDN | LRSYGDEEEE | PALSPPAALM |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| SLLSSQEELL | ENVLGCVPVG | QIVTVKPLSE | DFCYVLGYLL | TWKLILTFFK | AASSQLRALY |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| SMYLRKTKSL | NKLLYHLFRL | MPENPTYGET | AIEVSSKDPK | TFFTEEVQLS | IRETATLPYH |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| IPHLACSVYH | MTLKDLPAMV | RLWWNSSEKR | VFNIVDRFTS | KYVSNVLSFQ | EISSVQTSTQ |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LFNGMTVKAR | ATTREVMATY | TIEDIVIELI | IQLPSNYPLG | SITVESGKRI | GVAVQQWRNW |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| MLQLSTYLTH | QNGSIMEGLA | LWKNNVDKRF | EGVEDCMICF | SVIHGFNYSL | PKKACRTCKK |
| 1750 | 1760 | ||||
| KFHSACLYKW | FTSSNKSTCP | LCRETFF |