Q69Z66
PR
Gene name |
Mysm1 (Kiaa1915) |
Protein name |
Deubiquitinase MYSM1 |
Names |
2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320713 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q69Z66
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q69Z66-F1 | Predicted | AlphaFoldDB |
42 variants for Q69Z66
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388698894 | 89 | D>V | No | EVA | |
| rs28150759 | 106 | D>H | No | EVA | |
| rs28150759 | 106 | D>Y | No | EVA | |
| rs28150760 | 114 | H>Y | No | EVA | |
| rs3388673907 | 184 | K>I | No | EVA | |
| rs32719249 | 192 | A>G | No | EVA | |
| rs3388684034 | 196 | A>P | No | EVA | |
| rs3388695899 | 197 | C>F | No | EVA | |
| rs215737773 | 201 | S>N | No | EVA | |
| rs237005352 | 201 | S>R | No | EVA | |
| rs3388692627 | 222 | I>N | No | EVA | |
| rs3388695305 | 228 | E>D | No | EVA | |
| rs217161549 | 231 | S>C | No | EVA | |
| rs243317756 | 242 | T>S | No | EVA | |
| rs224450610 | 265 | A>T | No | EVA | |
| rs213180062 | 271 | S>Y | No | EVA | |
| rs3388698372 | 276 | K>N | No | EVA | |
| rs28150775 | 289 | A>T | No | EVA | |
| rs231291503 | 297 | S>N | No | EVA | |
| rs265520606 | 312 | V>L | No | EVA | |
| rs253200784 | 317 | T>A | No | EVA | |
| rs228526853 | 324 | R>T | No | EVA | |
| rs28150776 | 342 | S>R | No | EVA | |
| rs3388689085 | 362 | E>D | No | EVA | |
| rs3388695504 | 374 | R>G | No | EVA | |
| rs3394408495 | 445 | E>Q | No | EVA | |
| rs3394690816 | 448 | G>A | No | EVA | |
| rs3394623575 | 449 | A>P | No | EVA | |
| rs222962420 | 470 | A>V | No | EVA | |
| rs254178103 | 471 | A>T | No | EVA | |
| rs242618628 | 477 | E>D | No | EVA | |
| rs3388681414 | 503 | W>G | No | EVA | |
| rs3388691156 | 511 | G>R | No | EVA | |
| rs228225432 | 522 | M>L | No | EVA | |
| rs3388696210 | 586 | M>T | No | EVA | |
| rs261695973 | 588 | E>D | No | EVA | |
| rs3388692979 | 681 | M>L | No | EVA | |
| rs3388698304 | 687 | N>K | No | EVA | |
| rs28150846 | 701 | V>I | No | EVA | |
| rs28150870 | 750 | V>I | No | EVA | |
| rs3388681482 | 759 | D>E | No | EVA | |
| rs221057615 | 820 | M>S | No | EVA |
No associated diseases with Q69Z66
6 regional properties for Q69Z66
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| metal ion binding | Binding to a metal ion. |
| metal-dependent deubiquitinase activity | An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
| monoubiquitinated histone H2A deubiquitination | The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. |
| pigmentation | The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of hair follicle development | Any process that modulates the frequency, rate or extent of hair follicle development. |
| regulation of hemopoiesis | Any process that modulates the frequency, rate or extent of hemopoiesis. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5VVJ2 | MYSM1 | Deubiquitinase MYSM1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAEEADVDV | EGDVAAAAQP | GNDESTASVF | QDHYLDSTWR | RENGCLPWTL | DSTISDENRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IIEKMLLEEE | YYLSNKSLPG | KFWVNQKEDN | KKYTNSLQKS | SKAMVDSPAK | PASHSVKWTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEKELFEQGL | AKFGRRWTKI | ATLLKSRTVL | QVKSYARQYF | KNKVKWDVEK | ETPTQKSSSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQVKNKDDRT | KAWAAACLRG | SADPCLNAVK | IEKLSDDEDV | DITDELDELT | SQTSQNSGSH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTLDVPNSKM | YTTNQGELCQ | EGPLAKSSGE | SLQNVKQGEG | EACSSSEIAS | WAEKQKSTDK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSAELNEKYN | KVVEEHTLHR | GEVREEAKHS | PSPEPCERQD | SSGNEMLLPP | CQIEEENHEG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EELKPPEQEV | EIDRNVIQEE | EKQAIPEFFE | GRQTKTPERY | LKIRNYILDQ | WEICKPKYLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KTSVRPGLKN | CGDVNCIGRI | HTYLELIGAI | NFGCEQAVYN | RPQPLDKVRA | ADRKDAEAAY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QLAWRLQSMR | TRRRRVRDPW | GNWCDAKDLE | GQTFEHLSVE | EMARRKEEEK | CKPIKFSKAS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLPKSSLDPF | QLIPCNFFSE | EKQEPFQVKV | AAEALLIMNL | HAHVSMAEVI | GLLGGRYSEA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DKVLEVCAAE | PCNSLSTGLQ | CEMDPVSQTQ | ASETLALRGY | SVIGWYHSHP | AFDPNPSLRD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IDTQAKYQSY | FSRGGAKFIG | MIVSPYNRSN | PLPYSQITCL | VISEEVSPDG | TYRLPYKFEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QQMLEEPQWE | LVFEKTRWII | EKYRLSNSSV | PMDRIFRRDS | DLTCLQKLLE | CLRKTLSKVA |
| 790 | 800 | 810 | |||
| NCFIAEEFLT | QIENLFLSNY | KSKEENGLAE | EDSTKELFM |