Q68X45

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
KEGG Pathway
rty:RT0317
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

547-630 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q68X45

Entry ID Method Resolution Chain Position Source
AF-Q68X45-F1 Predicted AlphaFoldDB

No variants for Q68X45

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q68X45

No associated diseases with Q68X45

No regional properties for Q68X45

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q68X45

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLVIVESPA KAKTINKYLG DEFKVIASFG HIRDLPSKKG SVLPDKNFAM EYDISDKASK
70 80 90 100 110 120
YVDAIVKYAR KAEAVYLATD PDREGESISW HVAEVIKEKN KVESDDFFKR VAFNEITKKA
130 140 150 160 170 180
IIHAVENPRK LDTNLVNAQQ ARRALDYLVG FTLSPLLWRK LPGCKSAGRV QSVALRLICD
190 200 210 220 230 240
REDEIERFKA EEYWDISLKM QNSNNELFTA KLTHVNDQKL KKFSIINEKE AKDLTRKLKL
250 260 270 280 290 300
QKFYVEKIEK KQQKRQPQPP FITSSLQQEA ARKLGFSAKK TMQIAQKLYE GVDIGKETIG
310 320 330 340 350 360
LITYMRTDGV TLSNDAIADI RKLIDKNYGN KYLPINPRIY QSKVKNAQEA HEAIRPTNIT
370 380 390 400 410 420
YTPDNLKQKL EKDYYKLYEL IWQRTIACQM ENVIMDLVIA NLASENKEYL AKANGSIIAF
430 440 450 460 470 480
DGFYKVYRES LDDEDEEDNK MLPPLKAQEH IKTKEVIPNK HFTEPPPRYS EASLVKKLEE
490 500 510 520 530 540
LGIGRPSTYA SILSVLQDRK YVTLEKKRFI PEELGRLVTV FLVGFFKKYV EYDFTAGLEN
550 560 570 580 590 600
ELDEIAAGKL EWKTSLNNFW SGFNNNIESV NEQKITEIIN YLQKALDYHL FGENKESKVC
610 620 630 640 650 660
PSCKTGQLSL KLGKFGAFLA CSNYPECTFK KSIVSGNDNN EDEGNLSTIL NDNKILGTDK
670 680 690 700 710 720
DGVEIYLKTG PYGPYIQLGE QCGKVKPKRT PVPTNLKQSE ITLEVALKLL SLPLKIGIHK
730 740 750 760 770
DSGEEIIIGY SKFGPYIKYM CKFISVPKKY DFLNLNLDDA IKLIENNKAK LEKKHRSMV