Q68FS6

PR
Gene name
Pyroxd1
Protein name
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:297708
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-312 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q68FS6

Entry ID Method Resolution Chain Position Source
AF-Q68FS6-F1 Predicted AlphaFoldDB

No variants for Q68FS6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q68FS6

No associated diseases with Q68FS6

3 regional properties for Q68FS6

Type Name Position InterPro Accession
domain FAD/NAD(P)-binding domain 10 - 202 IPR023753-1
domain FAD/NAD(P)-binding domain 287 - 381 IPR023753-2
domain NADH-rubredoxin oxidoreductase, C-terminal 409 - 476 IPR041575

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, myofibril, sarcomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

2 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEAARPAGTF VVVGGGIAGV TCAEQLAINF PAEDILLVTA SPVIKAVTNF KQVSKVLEEF
70 80 90 100 110 120
DVEEQPSTML ENRFPNIKVI ESGVKQLKSD KHCIFTEDGR EYVYKKLCLC AGAKPKLICE
130 140 150 160 170 180
GNPYVLGIRD TDSAQEFQKQ LTKARRIMIV GNGGIALELA YEVEVCEVIW AIKDKAIGNT
190 200 210 220 230 240
FFDAGAAEFL TSRLLSEKSE AKLAHKRTIY TVEEAKKETS TKSKADYVGS ALGPDWHGGL
250 260 270 280 290 300
ALKGTEEFSH SIHIETKCEV KKIYLQEEFK IMKKKSLAFP KDHHKSVTVD KEMWPVYVEL
310 320 330 340 350 360
TNGSIYGCDF LVSATGVTPN VQPFLHGNDF DLGEDGGLRV DEQMRTSLPD IYAAGDICTA
370 380 390 400 410 420
CWPPSPVWQQ MRLWTQARQM GCYAAKCMAA ATMGHPIDMD FSFELFAHVT KFFNYKVVLL
430 440 450 460 470 480
GKYNAQGLGV DHELMLRCTR GQEYIKVVMH NGRMMGAVLI GETDLEETFE NLILNQMDLS
490
SYGEDLLNPD IDIEDYFD