Q67P77

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Symbiobacterium thermophilum (strain T / IAM 14863)
KEGG Pathway
sth:STH1531
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q67P77

Entry ID Method Resolution Chain Position Source
AF-Q67P77-F1 Predicted AlphaFoldDB

No variants for Q67P77

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q67P77

No associated diseases with Q67P77

9 regional properties for Q67P77

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 28 - 158 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 337 - 470 IPR001247-2
domain S1 domain 640 - 711 IPR003029
domain K Homology domain 568 - 638 IPR004087
domain K Homology domain, type 1 572 - 634 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 161 - 224 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 473 - 544 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 256 - 334 IPR015848
domain RNA-binding domain, S1 641 - 711 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPGAPDGPG HRRRTNVTAS FSMELGGRTM TLETGRLAKQ ASGSVLVNYG DSVVLCTAVG
70 80 90 100 110 120
SATPREGVDF FPLTVDYEER MYSVGRIPGN WFRREGRPTS KAILWARLTD RPIRPLFPEG
130 140 150 160 170 180
FRNDVQVVCT VLSVDPDHPV EIMGMIGASA ALTISDIPFE GPIGGVIVGL VDGQFVINPT
190 200 210 220 230 240
AEQQERSEMH LVVAGTEHAV LMVEAGAKEV PEQTMLDAIL FGHEVIKNTI IPTIKQMQAE
250 260 270 280 290 300
VGKPKREVVL FNPPPELEQA VREAATVRLR EAVRNPDKLA REEAVAAVGE AVQAELAEQF
310 320 330 340 350 360
PESEKHIAYL LKKVLKEEVR RAIIEEGIRP DGRSLTEIRP IECAVDLLPR PHGSGLFQRG
370 380 390 400 410 420
QTQVLSICTL GTLGDMQKLD DLTLEETKRF MHHYNFPPYS VGETRPLRGP GRREIGHGAL
430 440 450 460 470 480
AERALEPVIP PEEEFPYTIR VVSEVLESNG SSSMASVCGS TLALMAAGVP IKAPVAGVAM
490 500 510 520 530 540
GLVEDPETGR YAVLTDIQGI EDALGDMDFK VAGTKKGVTA LQMDMKISGT SREILEKALM
550 560 570 580 590 600
QAREGRMFIM EKMLACISEP RKELSPWAPR IITMKISPEK IRDVIGKGGS TINKIIEETK
610 620 630 640 650 660
VGHTKVEIDI QDDGTIYIAA VNLEAGERAR QMIEALVKDP EPGMIYTGRV TRLMQFGAFV
670 680 690 700 710 720
EILPGKEGLV HISELSDKRV ARVEDVVNIG DEVTVKVTEI DRLGRINLSI KDAMPKQAAS
730 740 750 760
QPSGRPEARQ PQPKPGQGKP GPAKAGAGRP GPGKPGPGRH GR