Q67NB6

PR
Gene name
dxs
Protein name
1-deoxy-D-xylulose-5-phosphate synthase
Names
1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS
Species
Symbiobacterium thermophilum (strain T / IAM 14863)
KEGG Pathway
sth:STH1842
EC number
2.2.1.7: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

591-648 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q67NB6

Entry ID Method Resolution Chain Position Source
AF-Q67NB6-F1 Predicted AlphaFoldDB

No variants for Q67NB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q67NB6

No associated diseases with Q67NB6

3 regional properties for Q67NB6

Type Name Position InterPro Accession
domain Transketolase, N-terminal 28 - 47 IPR005474
domain Transketolase-like, pyrimidine-binding domain 312 - 475 IPR005475
domain Transketolase, C-terminal domain 487 - 608 IPR033248

Functions

Description
EC Number 2.2.1.7 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHLRDLTGPE QLKRLAPAEL AQLAAEIRRV ILETVATNGG HLAPNLGVVE LTLALHIVFD
70 80 90 100 110 120
SPRDKILWDV SHQSYVHKLL TGRLHQFHTL RQFGGIAGFT DPRESVHDHF HWGHASTSIS
130 140 150 160 170 180
AAVGMAKARD LAGDDYEVVA VIGDGALTGG MAYEALDHAG HDKTKVIVVL NDNSMSIAPN
190 200 210 220 230 240
VGGISNYLAR IRTGPSYQRV KHDVAEALRQ IPLIGPQALE LADRLKEGVK HLLVHNMFFE
250 260 270 280 290 300
DLGFTYLGPV DGHNVSALVD VLRQARAYPG PTVVHVVTTK GKGVPYAEQL PDKFHGGGPF
310 320 330 340 350 360
DVATGRTGPG SLTYSEVFGN VMCKLAAEDP RVCAITAAMP SGTGLSRFAR QFPDRYFDVG
370 380 390 400 410 420
IAEQHAVTFA AGLAKGGMRP VFAVYSTFLQ RAYDQVIHDV ALQNLPVTLA IDRGGLVEDG
430 440 450 460 470 480
ATHQGVFDVA YLRAIPNMVV MAPKDENELQ HMLYTALCHD GPAALRYPRG KAQGVPLDET
490 500 510 520 530 540
LQPLPIGRGE VMQEGADVAL IGLGTMARVC QEAARLLAEK SISAMVINPR FVKPLDAELL
550 560 570 580 590 600
LRAGREVGAV VTVEEACLAG GFGSAVLELY AAHGVNARVE RMGIPDEFVD HGQPARYLER
610 620 630 640
YGLTPEGVAQ RAEALLLRMR SDLAAQPARR SRSVRRLSGA KAAGNGET