Q67MV8

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Symbiobacterium thermophilum (strain T / IAM 14863)
KEGG Pathway
sth:STH2000
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

333-475 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q67MV8

Entry ID Method Resolution Chain Position Source
AF-Q67MV8-F1 Predicted AlphaFoldDB

No variants for Q67MV8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q67MV8

No associated diseases with Q67MV8

5 regional properties for Q67MV8

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 869 IPR003156
domain Aminoacyl-tRNA synthetase, class II 62 - 255 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 698 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 711 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSAEIRQKF IDFFKSKGHV HVPSSSLVPH NDPTLLFTNA GMNQFKDTFL GLEKREYTRA
70 80 90 100 110 120
VTAQKCVRAG GKHNDLDEVG FTARHHTFFE MLGNFSFGDY FKEDALAYAW EFITSPEWLG
130 140 150 160 170 180
LPKDRLWVSI YKDDEQAFDV WHNKVGVPAD RIVRLGEKDN FWRMGDTGPC GPCSEIFWDM
190 200 210 220 230 240
GPEYACDHPD GCRIDTCGCD RWREFWNNVF MQYNQTPEGL VPLERTGVDT GLGLERMATI
250 260 270 280 290 300
MQGVWSNWDI DLWQPIFARI HELSGKKYEG EGPEAVAFRV IADHARCCTF LIADGVRFSN
310 320 330 340 350 360
EGRGYVMRRI LRRAVRFGRV LGFAEPFIWK VAGAVADVMG DAYPEVRERL PVIQDELRRE
370 380 390 400 410 420
EERFLRTLEQ GMNRLEEILA RMRQKGETVI SGQDAFVLYD TYGFPLDIVR DVAREQGFTV
430 440 450 460 470 480
DEQGYQAAMA EQRARARAAR DVSYITEVQS RIAGHLEGVA PTRFVGYTEL AGEGRVLAVF
490 500 510 520 530 540
DQEGNATGAG EGSSVIIVLD RTPFYAEGGG QVGDTGQIVA PGLRVEVEDC RKLPSGHHLH
550 560 570 580 590 600
YGTVQEGFLE VGQQVEARVD ARKRKDTQKN HTATHLLHKA LREVLGTHVQ QAGSLVAPDR
610 620 630 640 650 660
LRFDFTHTGP MTPEQIAAVE EMINAEIEAA EPVTWTEMPL DEARALGAMA LFGEKYGEIV
670 680 690 700 710 720
RVVSVGDGWS RELCGGCHVS NTSEVQYFKI LSESGIGGGV RRIEAVTGPG VIRHLEEAQA
730 740 750 760 770 780
RAVEAQEQLR SRMKEMEKEL EQLRAKLAAS QTDSLVERAQ EVGGVKVVAG TAPVATMEDL
790 800 810 820 830 840
RNMTDAIRAK LGSGVVVLGA VTSEGKVNLV AAVTKDLAGR VHAGNLIREV ARICGGGGGG
850 860 870
RPDMATAGGK NPERLGEALN AVPGLVGSQL GL