Q67E01

PR
Gene name
dstyk (ripk5)
Protein name
Dual serine/threonine and tyrosine protein kinase
Names
Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:446954
EC number
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

783-803 (Activation loop from InterPro)

Target domain

641-895 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q67E01

Entry ID Method Resolution Chain Position Source
AF-Q67E01-F1 Predicted AlphaFoldDB

No variants for Q67E01

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q67E01

No associated diseases with Q67E01

4 regional properties for Q67E01

Type Name Position InterPro Accession
domain Protein kinase domain 641 - 895 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 643 - 890 IPR001245
active_site Serine/threonine-protein kinase, active site 762 - 774 IPR008271
binding_site Protein kinase, ATP binding site 647 - 670 IPR017441

Functions

Description
EC Number 2.7.12.1 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Apical cell membrane
  • Basolateral cell membrane
  • Cell junction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

1 GO annotations of biological process

Name Definition
embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRDGTRSAR RMDEGDRRTG SAGRSGSREL GRGFSYYNKY LARLQQNLRD TKRFFRDIKL
70 80 90 100 110 120
TYSGAPGGPD TEFSGAEGEF GQLHSITFPR QEEEYLKLTV RCRPCIFILG QNCSGRGRVA
130 140 150 160 170 180
NGLLGGQLLP ILTHGDIECC KRRRIRFRHG KQTLVSLALP EQYELVHQLV AHQGKWDTIP
190 200 210 220 230 240
EEDLDVPEDE EDPAHRLAEL EVTLPHQLLQ DVDIVVSPCR SSQAVSMTLE DYVDHVQSIV
250 260 270 280 290 300
VYAVSEEMLS KQDEEELTEI KEKYKLPVFF IRTSSTKDRL IGGSEGVRSV LYEQLIELGY
310 320 330 340 350 360
LQRGLCNCGA AGSGSTAPSM LVEQFEKIRQ LSTFSRQVLQ MHLVDAAIVL NMVHSRCLDL
370 380 390 400 410 420
FINKAFDMHR DLQITPKRLE YTRQKENELY ESLMRISDRK QEELKDMIVE TLNSMREQLL
430 440 450 460 470 480
EDAANMQFKD IVIPQNGEPV SAHEVKCCIF QIKELIISRL NQAVVNKLIS SVDYLRESFV
490 500 510 520 530 540
GTMERCLRSL EKSQQESSSH VTSNHLKQIL NAAYHVEVTF NSGSTVTRMV WEQIVQIIQR
550 560 570 580 590 600
ITWVSPPTIT PEWKRRVAQD AIETLSASKL AKSICSQFCK RLKSSHEAFA ASLKQLEVGH
610 620 630 640 650 660
SGRLEKTNDL WLRVRKDHAP RLARLSLESR SLQDVLLHGK PRIGRELGRG QYGVVYLCDS
670 680 690 700 710 720
WGGHFPCALK SVVPPDEKHW NDLALEFHYM RSLPKHERLV DLHGSVIDYS YGGGSSIAVL
730 740 750 760 770 780
LITERLHRDL YVGLKTGLSL ETRLQIALDV VEGIRFLHNQ GVVHRDIKLK NVLLDKKHRA
790 800 810 820 830 840
KITDLGFCKP EAMMSGSIVG TPIHMAPELF SGKYDNSVDV YAFGILFWYI CSGSVKLPEA
850 860 870 880 890 900
FEKCASKDHL WNNVRKGARP ERLTIFDEEC WKLMEACWNG DPSQRPLMGI VQPMLQGIMD
910
RLCHTQETGK ALEDST