Q66T60

PR
Gene name
L
Protein name
Large structural protein
Names
Protein L, Replicase, Transcriptase
Species
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
KEGG Pathway
EC number
2.1.1.375: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

453-524 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q66T60

Entry ID Method Resolution Chain Position Source

No variants for Q66T60

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q66T60

No associated diseases with Q66T60

2 regional properties for Q66T60

Type Name Position InterPro Accession
conserved_site Intermediate filament protein, conserved site 374 - 382 IPR018039
domain Intermediate filament, rod domain 76 - 388 IPR039008

Functions

Description
EC Number 2.1.1.375 Methyltransferases
Subcellular Localization
  • Virion
  • Host cytoplasm
  • L and P are packaged asymmetrically towards the blunt end of the virus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

1 GO annotations of biological process

Name Definition
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMIDPGEVYD DPIDLIESEA EPKGNPTIPN ILRNSDYNLN SPLIEDPARL MLEWLKTGNR
70 80 90 100 110 120
PLRMTLTDNC SRSHKVLKDY FKRVDLGSLK VGGAAAQSMI SLWLYGAHSE SNRSRKCIND
130 140 150 160 170 180
LAQFYYKSSP IEKLLNCTLG NRGLKTPPEG VLSCLARVDY DKAFGRYLAN IYSSYLFFHV
190 200 210 220 230 240
ITLYMNALDW DEEKTILALW RDITSIDTGK DLVKFKDQIW GLLIVTKDFV YSQSTGCLFD
250 260 270 280 290 300
RNYTLMLKDL FLSRFNSLMI LLSPPEPRYS DDLISQLCQL YIAGDQVLSM CGNSGYEVIK
310 320 330 340 350 360
ILEPYVVNSL VQRAEKFRPL IHSLGDFPTF IRDKVGQLEG TFGPSAKRFF KVLDQFDNIH
370 380 390 400 410 420
DLVFVYGCYR HWGHPYIDYR KGLSKLYDQV HLKKVIDKSY QECLASDLAR RILRWGFDKY
430 440 450 460 470 480
SKWYLDSRLL SRDHPLIPYI KTQTWPPRHI VDLVGDTWHK LPITQIFEIP ESMDPSEILD
490 500 510 520 530 540
DKSHSFTRTR LASWLSENRG GPVPSEKVII TALSKPPVNP REFLKSIDLG GLPDEDLIIG
550 560 570 580 590 600
LKPKERELKI EGRFFALMSW NLRLYFVITE KLLANYILPL FDALTMTDNL NKVFKKLIDR
610 620 630 640 650 660
VTGQGLLDYS RVTYAFRLDY EKWNNHQRLE STEDVFSVLD QVFGLKRVFS RTHEFFQRSW
670 680 690 700 710 720
IYYSDRSDLI GLWEDQIYCL DMSDGPTCWN GQDGGLEGLR QKGWSLVSLL MIDRESQTRN
730 740 750 760 770 780
TRTKILAQGD NQVLCPTYML SPGLSREGLL YELESISRNA LSIYRAIEEG ASKLGLIIKK
790 800 810 820 830 840
EETMCSYDFL IYGKTPLFRG NILVPESKRW ARVSCISNDQ IVNLANTMST VSTNALTVAQ
850 860 870 880 890 900
HSQSLIKPMR DFLLMSVQAV FHYLLFSPIL KGRVYKILSA EGDNFLLAMS RIIYLDPSLG
910 920 930 940 950 960
GVSGMSLGRF HIRQFSDPVS EGLSFWREIW LSSNESWIHA LCQEAGNPDL GERTLESFTR
970 980 990 1000 1010 1020
LLEDPTTLNI KGGASPTILL KDAIRKALYD EVDEVENSEF REAILLSKTH RDNFILFLKS
1030 1040 1050 1060 1070 1080
IEPLFPRFLS ELFSSSFLGI PESIIGLIQN SRTIRRQFRR SLSRTLEESF YNSETHGINR
1090 1100 1110 1120 1130 1140
MTQTPQRVGR VWPCSSERAD LLREISWGRK VVGTTVPHPS EMLGLIPKSS ISCTCGAAGG
1150 1160 1170 1180 1190 1200
GNPRISVSVL PSFDQSFFSR GPLKGYLGSS TSMSTQLFHA WEKVTNVHVV KRALSLKESI
1210 1220 1230 1240 1250 1260
NWFITRNSNR AQTLIRNIMS LTGPDFPLEE APVFKRTGSA LHRFKSARYS EGGYSSVCPN
1270 1280 1290 1300 1310 1320
LLSHISVSTD TMSDLTQDGR NYDFMFQPLM LYAQTWTSEL VQKDTRLKDS TFHWHLRCNK
1330 1340 1350 1360 1370 1380
CIRPIDDMTL DTSQVFEFPD VSRRISRMVS GAVPHFRKLP DIRLRPGDFE SLSGKEKSRH
1390 1400 1410 1420 1430 1440
IGSAQGLLYS ILVAIHDSGY NDGTIFPVNI YSKVSPRDYL RGLARGVLIG SSICFLTRMT
1450 1460 1470 1480 1490 1500
NININRPLEL ISGVISYILL RLDNHPSLYI MLREPSLRGE IFSIPQKVPA AYPTTMKEGN
1510 1520 1530 1540 1550 1560
RSILCYLQHV LRYEREAITA SPENDWLWIF SDFRSSKMTY LTLITYQSHL LLQRVDKNLS
1570 1580 1590 1600 1610 1620
KSMRANLRQM SSLMRQVLGG HGEDTLESDE DIQRLLKDSL RRTRWVDQEV RHAARTMTGS
1630 1640 1650 1660 1670 1680
YSPHRRVSRK AGCSEWVCSA QQVAVSTSAN PAPASELDIR TLSRRLQNPL ISGLRVVQWA
1690 1700 1710 1720 1730 1740
TGAHYKLKPI LDDLNVFPSL CLVVGDGSGG ISRAVLNMFP DARLVFNSLL EVNDLMASGT
1750 1760 1770 1780 1790 1800
HPLPPSAIMS GGDDIISRVI DFDSIWEKPS DLRNLTTWRY FQSVQEQVNM SYDLIICDAE
1810 1820 1830 1840 1850 1860
VTDIASINRI TLLMSDFALS IDGPLYLVFK TYGTMLVNPD YRAIQHLSRA FPAVTGFITQ
1870 1880 1890 1900 1910 1920
MTSSFSSELY LRFSKRGKFF RDAEYLTSST LREMSLVLFN CSSPKSEMQR ARSLNYQDLV
1930 1940 1950 1960 1970 1980
RGFPDEVISN PYNEMIITLI DSDVESFLVH KMVDDLELQR GTLSKVSIII AIMIVFSNRV
1990 2000 2010 2020 2030 2040
FNVSKPLTDP LFYPPFDPKI LRHFNICCST MMYLSTALGD VPSFARLHDL YNRPITYYFR
2050 2060 2070 2080 2090 2100
KQVIRGNIYL SWSWSDDTSV FKRVACNSSL SLSSHWIRLI YKIVKTTRLV GSIEDLSGEI
2110 2120
EKHLRGYNRW ITLDDIRSRS SLLDYSCL