Q66KH9

PR
Gene name
cdk8
Protein name
Cyclin-dependent kinase 8
Names
Cell division protein kinase 8, Mediator complex subunit cdk8, Mediator of RNA polymerase II transcription subunit cdk8
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:447409
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

278-416 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q66KH9

Entry ID Method Resolution Chain Position Source
AF-Q66KH9-F1 Predicted AlphaFoldDB

No variants for Q66KH9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q66KH9

No associated diseases with Q66KH9

3 regional properties for Q66KH9

Type Name Position InterPro Accession
domain Protein kinase domain 21 - 287 IPR000719
active_site Serine/threonine-protein kinase, active site 147 - 159 IPR008271
binding_site Protein kinase, ATP binding site 27 - 52 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYDFKVKLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDRDYA LKQIEGTGIS
70 80 90 100 110 120
MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDFA EHDLWHIIKF HRASKANKKP
130 140 150 160 170 180
VQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF
190 200 210 220 230 240
NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDKDWE DIKKMPEHST LIKDFRRNTY
250 260 270 280 290 300
TNCSLIKYME KHKVKPDSKT FHLLQKLLTM DPIKRISSEQ AMQDPYFLED PLPTSDVFAG
310 320 330 340 350 360
CQIPYPKREF LTEEEPDDKG DKKNQQQQQG NNHTNGTGHP GNQDNSHAQG PPLKKVRVVP
370 380 390 400 410
PTTTSGGLIM TSDYQRSNPH AAYQNPGPST SQPQSSMGYT STSQQPPQYS HQTHRY