Q66JX5

PR
Gene name
Cep43
Protein name
Centrosomal protein 43
Names
FGFR1 oncogene partner
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:75296
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

170-245 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q66JX5

Entry ID Method Resolution Chain Position Source
AF-Q66JX5-F1 Predicted AlphaFoldDB

16 variants for Q66JX5

Variant ID(s) Position Change Description Diseaes Association Provenance
20 L>R strain: C57BL/6J [UniProt] No
rs224586042 61 N>S No EVA
rs257597205 112 Q>R No EVA
rs48213049 186 I>S No EVA
rs51715587 190 P>S No EVA
rs3389447455 216 S>N No EVA
rs3389447402 217 L>Q No EVA
rs3389391865 218 H>N No EVA
rs3389434921 222 H>L No EVA
rs215314707 274 R>W No EVA
rs51906200 277 V>M No EVA
rs3389430840 298 G>* No EVA
rs3389412057 352 E>Q No EVA
rs3389432187 354 S>N No EVA
rs3389412102 364 S>P No EVA
rs232891142 370 G>V No EVA

No associated diseases with Q66JX5

2 regional properties for Q66JX5

Type Name Position InterPro Accession
domain LIS1 homology motif 70 - 102 IPR006594
domain FGFR1 oncogene partner (FOP), N-terminal dimerisation domain 54 - 134 IPR018993

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Cytoplasm, cytoskeleton, cilium basal body
  • Associated with gamma-tubulin
  • Localizes on both mother and daughter centrioles
  • Localizes to an axial position on the mother centriole
  • Localizes to the distal end of the centriole partly to the subdistal appendage region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

3 GO annotations of molecular function

Name Definition
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a protein tyrosine kinase.

6 GO annotations of biological process

Name Definition
cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
microtubule anchoring Any process in which a microtubule is maintained in a specific location in a cell.
negative regulation of protein kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAATTAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK VENKTPLVNE
70 80 90 100 110 120
NLKKFLNTKD GRLVASLVAE FLQFFNLDFT LAVFHPETST IQGLEGRENL AQDLGIIEAE
130 140 150 160 170 180
GTVGGPLLLE VIRRCQQKEK GPASVEGALD LSDGHPPSKS PEGKSSANST PSKIPRYKGQ
190 200 210 220 230 240
GKKKTIGQKP GDKKTSSETS QSEPSVSLSE SKSKSSLHSL AHETRIASFL SSSAVDARDS
250 260 270 280 290 300
SALCPDGDDV EGDSFFDDPI PKPEKTYGWR AEPRKQVGGL ASLSDKPHLR SGLSSLAGAP
310 320 330 340 350 360
SLTDPESKRG STVLKDLKLV GEKIGSLGLG TGEDEDYADD FNSASHRSEK SELSIGEEIE
370 380 390
EDLSMGVEDG NTSDKLDDLT QDLTVSQLSD VADYLEDVA