Q66HG6
Gene name |
Ca5b (Car5b) |
Protein name |
Carbonic anhydrase 5B, mitochondrial |
Names |
Carbonate dehydratase VB, Carbonic anhydrase VB, CA-VB |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:302669 |
EC number |
4.2.1.1: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q66HG6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q66HG6-F1 | Predicted | AlphaFoldDB |
1 variants for Q66HG6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3323631688 | 109 | T>S | No | EVA |
No associated diseases with Q66HG6
1 regional properties for Q66HG6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 466 - 475 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.1 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| carbonate dehydratase activity | Catalysis of the reaction: H2CO3 = CO2 + H2O. |
| hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43165 | Ca5a | Carbonic anhydrase 5A, mitochondrial | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVMSHLRVS | LQVSSCTLLW | RRFRVPRLVP | LRSCSLYTCT | YRTRNRALPP | LWENLDLVPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDRQSPINIR | WRDSVYDPGL | KPLTISYDPA | TCLHIWNNGY | SFLVEFEDTT | DKSVIEGGPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EHNYRLKQFH | FHWGAIDAWG | SEHTVDSKCY | PAELHLVHWN | AVKFESFEDA | ALEENGLAVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVFLKLGKHH | KELQKLVDTL | PSIKHKDTLV | KFGSFDPSCL | MPTCPDYWTY | SGSLTTPPLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESVTWIIKKQ | PVEVDHDQLE | QFRTLLFTSE | GEKEKRMVDN | FRPLQPLMNR | TVRSSFRHDY |
| 310 | |||||
| VLNIQVKPEP | TASEVSP |