Q65RQ2

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Mannheimia succiniciproducens (strain MBEL55E)
KEGG Pathway
msu:MS1751
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q65RQ2

Entry ID Method Resolution Chain Position Source
AF-Q65RQ2-F1 Predicted AlphaFoldDB

No variants for Q65RQ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q65RQ2

No associated diseases with Q65RQ2

4 regional properties for Q65RQ2

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 65 - 76 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 35 - 647 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 692 - 849 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 647 - 827 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVRKMSEQKD YKNTLNLPET GFPMRGDLAK REPGMLKNWY DNDLYQKIRQ SSKGKKSFIL
70 80 90 100 110 120
HDGPPYANGS IHIGHAVNKI LKDIIIKSKT ALGFDSPYIP GWDCHGLPIE LKVEGLVGKP
130 140 150 160 170 180
NQKISAAQFR EECRKYAREQ VEGQKKDFIR LGVLGDWDNP YLTMNFDTEA NIIRAFGKAV
190 200 210 220 230 240
ANGHLYKGSK PVHWCLDCAS SLAEAEVEYE DRTSPSIYVR FAAADESAVE NKFVLTEQGK
250 260 270 280 290 300
GKLSAVIWTT TPWTLPSNKA ISINPELEYQ IVQFGDERFI LAAELVESVA QAVGVESWKA
310 320 330 340 350 360
LGSAKGSDLE LLQFKHPFYD YNVPFILGDH VTLDGGTGLV HTAPDHGQDD YVVARKYNIG
370 380 390 400 410 420
MAGLIGNDGK FNSNAKFFAG LGVFEANGKV LEKLDEVGAL LKLEKIRHSY PHCWRHKTPI
430 440 450 460 470 480
IFRATPQWFI GMETQGLRQQ ALSEIKKVRW IPDWGQARIE KMVENRPDWC ISRQRTWGVP
490 500 510 520 530 540
VALFIHKETE QLHPRTLELI EEVAKLVERK GIQAWWDLDA KDLLGDDAAH YSKVPDTLDV
550 560 570 580 590 600
WFDSGSTYYS VVKNRPEFNG KEADMYLEGS DQHRGWFMSS LMLSTATDNK APYKQVLTHG
610 620 630 640 650 660
FTVDGQGRKM SKSIGNIVTP QEVMDKFGGD ILRLWVASTD YTGEMTVSDE ILKRAADSYR
670 680 690 700 710 720
RIRNTARFLL ANLNGFDPKR DLVQAHEMIS LDRWAVDCAF RAQAEIKEAY DNYQFHTVVQ
730 740 750 760 770 780
RLMKFCSVEM GSFYLDIIKD RQYTTKADSL ARRSCQTALW HIAEALVRWM APILSFTADE
790 800 810 820 830 840
IWGYLPGERG EFVFTEEFYD GLFALDVSES LDDAYWQQVI TVRNEVNRVL EQARNDKVIG
850 860 870 880 890 900
GGLEAEVTIF ANDEYSALLN KLGNELRFVT ITSKAEVKTL ADADVAEGEV AGLAIKAIRS
910 920 930
ANHKCPRCWH YSDSKDANSL CSRCEENVNG NGEERRFA