Q65JJ3
Gene name |
dxr |
Protein name |
1-deoxy-D-xylulose 5-phosphate reductoisomerase |
Names |
DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase |
Species |
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) |
KEGG Pathway |
bli:BL01237 |
EC number |
1.1.1.267: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q65JJ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q65JJ3-F1 | Predicted | AlphaFoldDB |
No variants for Q65JJ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q65JJ3 | |||||
No associated diseases with Q65JJ3
3 regional properties for Q65JJ3
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.267 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity | Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH. |
| metal ion binding | Binding to a metal ion. |
| NADPH binding | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. |
| terpenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKNICLLGAT | GSIGEQTLDV | IKAHDDKFRL | TAMTFGKNAE | KAAEIIETFK | PKYVGVGDEH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TYETLKQHSF | SYTFKTGIGE | EALIEAAVIP | EADIVVNALV | GSVGLLPTLK | AMEHKKTIAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ANKETLVTAG | HIVKEHAQKY | DVPLLPVDSE | HSAIFQALQG | ENPKHIKRLI | VTASGGSFRD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RTRRELEGVT | VEEALNHPNW | SMGAKITIDS | ATMMNKGLEV | IEAHWLFDLP | YDQIDVLLHK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESIIHSMVEF | HDRSVIAQLG | TPDMRVPIQY | ALSHPERLPF | NEAKSLDLWE | VGQLNFAQAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FERFRCLQFA | YESGKIGGTM | PTVLNAANEE | AVAAFLSGRI | SFLGIEDIIE | KALERHQVIA |
| 370 | 380 | ||||
| KPSLQEIREV | DKDARKFVQT | LLT |